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Defect-related luminescent nanostructured hydroxyapatite promotes mineralization through both intracellular and extracellular pathways
- Source :
- RSC Advances. 9:35939-35947
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- Hydroxyapatite (HAP) is a widely used biomaterial for bone tissue substitution due to its chemical similarity with the natural bone. Defect-related luminescent HAP materials have the same chemical composition as normal HAP and excellent biocompatibility. However, only few works have focused on the defect-related luminescent HAP materials on bone regeneration. In this work, we systematically investigated the bone regeneration pathway induced by nanostructured particles using defect-related luminescent hydroxyapatite (S2) materials. We monitored the subcellular distribution and location of S2 during osteoblast differentiation with the property of defect-related luminescence. Nano-scale S2 could be internalized by osteoblasts (OBs) via caveolae-mediated endocytosis and macropinocytosis. S2 incorporated into the lysosomes dissolved and released calcium ions for the formation of mineralized nodules. Extracellular S2 also promoted bone regeneration as a nucleation site. Taken together, the physical properties of hydroxyapatite control the bone regeneration pathway in osteoblasts.
- Subjects :
- T1
Biocompatibility
Chemistry
General Chemical Engineering
Pinocytosis
TN
Biomaterial
Osteoblast
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Bone tissue
Endocytosis
01 natural sciences
0104 chemical sciences
medicine.anatomical_structure
stomatognathic system
medicine
Extracellular
Biophysics
QE
0210 nano-technology
Bone regeneration
RD
Subjects
Details
- ISSN :
- 20462069
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- RSC Advances
- Accession number :
- edsair.doi.dedup.....8ee8973bd61c2d5cef6c469f105876b8