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Radiolabeling Strategies of Nanobodies for Imaging Applications
- Source :
- Diagnostics, Diagnostics, Vol 11, Iss 1530, p 1530 (2021)
- Publication Year :
- 2021
-
Abstract
- Nanobodies are small recombinant antigen-binding fragments derived from camelid heavy-chain only antibodies. Due to their compact structure, pharmacokinetics of nanobodies are favorable compared to full-size antibodies, allowing rapid accumulation to their targets after intravenous administration, while unbound molecules are quickly cleared from the circulation. In consequence, high signal-to-background ratios can be achieved, rendering radiolabeled nanobodies high-potential candidates for imaging applications in oncology, immunology and specific diseases, for instance in the cardiovascular system. In this review, a comprehensive overview of central aspects of nanobody functionalization and radiolabeling strategies is provided.
Details
- ISSN :
- 20754418
- Volume :
- 11
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Diagnostics (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....8eded83c7486a0ccca15d1666760d1ca