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Radiolabeling Strategies of Nanobodies for Imaging Applications

Authors :
Ralph A. Bundschuh
Markus Essler
Jim Küppers
Stefan Kürpig
Susanne Lütje
Source :
Diagnostics, Diagnostics, Vol 11, Iss 1530, p 1530 (2021)
Publication Year :
2021

Abstract

Nanobodies are small recombinant antigen-binding fragments derived from camelid heavy-chain only antibodies. Due to their compact structure, pharmacokinetics of nanobodies are favorable compared to full-size antibodies, allowing rapid accumulation to their targets after intravenous administration, while unbound molecules are quickly cleared from the circulation. In consequence, high signal-to-background ratios can be achieved, rendering radiolabeled nanobodies high-potential candidates for imaging applications in oncology, immunology and specific diseases, for instance in the cardiovascular system. In this review, a comprehensive overview of central aspects of nanobody functionalization and radiolabeling strategies is provided.

Details

ISSN :
20754418
Volume :
11
Issue :
9
Database :
OpenAIRE
Journal :
Diagnostics (Basel, Switzerland)
Accession number :
edsair.doi.dedup.....8eded83c7486a0ccca15d1666760d1ca