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Inhibitory Effects of Nabumetone, a Cyclooxygenase‐2 Inhibitor, and Esculetin, a Lipoxygenase Inhibitor, on N‐Methyl‐N‐nitrosourea‐induced Mammary Carcinogenesis in Rats
- Source :
- Japanese Journal of Cancer Research : Gann
- Publication Year :
- 1998
- Publisher :
- Blackwell Publishing Ltd, 1998.
-
Abstract
- We investigated the modifying effects of nabumetone, a relatively selective cyclooxygenase-2 inhibitor, and esculetin, a lipoxygenase inhibitor, on N-methyl-N-nitrosourea(MNU)-induced mammary carcinogenesis in female Sprague-Dawley rats. A total of 124 rats, 6 weeks old, were divided into 6 groups. At 50 days of age, groups 1, 2, and 3 were treated with MNU (50 mg/kg body weight) by subcutaneous injection. From the age of 8 weeks, groups 2 and 4 were given 0.03% nabumetone in the diet and groups 3 and 5 were given 0.03% esculetin in the diet. All rats were necropsied at the termination (25 weeks after the start of experiment). The incidence and multiplicity of neoplasms in group 2 were significantly smaller than those in group 1 (P < 0.005 and P < 0.001, respectively). The incidence of neoplasms in group 3 was also significantly smaller than that in group 1 (P < 0.05). These results indicate that the intake of nabumetone or esculetin during the time corresponding to the post initiation phase has a chemopreventive effect on MNU-induced mammary carcinogenesis in rats.
- Subjects :
- Cancer Research
medicine.medical_specialty
Time Factors
Cyclooxygenase‐2
Nabumetone
Mammary gland
Lipoxygenase
Chemoprevention
Article
Rats, Sprague-Dawley
Subcutaneous injection
Internal medicine
medicine
Animals
Cyclooxygenase Inhibitors
Lipoxygenase Inhibitors
Umbelliferones
Enzyme Inhibitors
Anticarcinogen
Carcinogen
biology
Cyclooxygenase 2 Inhibitors
Chemistry
Mammary Neoplasms, Experimental
Methylnitrosourea
Key words
Butanones
Rat mammary carcinogenesis
Rats
Isoenzymes
Endocrinology
medicine.anatomical_structure
Oncology
Enzyme inhibitor
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
biology.protein
Carcinogens
Female
Cyclooxygenase
Cell Division
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 18764673 and 09105050
- Volume :
- 89
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Cancer Research : Gann
- Accession number :
- edsair.doi.dedup.....8eda76a1adec5463cd0fdbab26639039