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Modulation of nicotine effects on selective attention by DRD2 and CHRNA4 gene polymorphisms
- Source :
- Psychopharmacology. 232:2323-2331
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Pharmacological and genetic modulation of cholinergic nicotinic neurotransmission influence visuospatial attention in humans. Prior studies show that nicotine as well as a single nucleotide polymorphism (SNP) in the gene coding for the alpha 4 subunit of the nicotinic acetylcholine receptor (CHRNA4) modulate visuospatial attention and distractor interference. The CHRNA4 gene synergistically interacts with a polymorphism in the dopaminergic receptor type d2 (DRD2) gene and impacts brain structure and cognition. We aimed to investigate whether CHRNA4 and DRD2 genotypes alter the effects of nicotine on distractor interference. Fifty-eight young healthy non-smokers were genotyped for CHRNA4 (rs1044396) and DRD2 (rs6277). They received either 7 mg transdermal nicotine or a matched placebo in a double-blind, within-subject design 1 h prior to performing a visual search task with distractors. In isolation, DRD2 but not CHRNA4 genotype modulated the effects of nicotine on distractor interference with DRD2 CC carriers showing the strongest reduction of distractor interference after nicotine administration. A further analysis provided additional evidence that this effect was driven by those subjects, who carried at least one C allele in the CHRNA4 gene. The effects of nicotine on distractor interference are modulated synergistically by cholinergic and dopaminergic genetic variations. Hence, both genes may contribute to the often reported individual variability in cognitive and neural effects of nicotine.
- Subjects :
- Adult
Male
Nicotine
Alpha (ethology)
Single-nucleotide polymorphism
Receptors, Nicotinic
Pharmacology
Biology
Administration, Cutaneous
Polymorphism, Single Nucleotide
Young Adult
Double-Blind Method
Reaction Time
medicine
Humans
Attention
Prospective Studies
Cross-Over Studies
Receptors, Dopamine D2
Dopaminergic
Genetic Variation
Nicotinic acetylcholine receptor
Nicotinic agonist
Cholinergic
Neuroscience
Photic Stimulation
Acetylcholine
medicine.drug
Subjects
Details
- ISSN :
- 14322072 and 00333158
- Volume :
- 232
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....8ed0f951cae4049780bcee5760860d25