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Mn-Doped Glass–Ceramic Bioactive (Mn-BG) Thin Film to Selectively Enhance the Bioactivity of Electrospun Fibrous Polymeric Scaffolds

Authors :
Mariangela Curcio
Brigida Bochicchio
Antonietta Pepe
Antonio Laezza
Adriana De Stefanis
Julietta V. Rau
Roberto Teghil
Angela De Bonis
Source :
Coatings; Volume 12; Issue 10; Pages: 1427
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

In recent years, significant progress has been made in the development of new technologies to meet the demand for engineered interfaces with appropriate properties for osteochondral unit repair and regeneration. In this context, we combined two methodologies that have emerged as powerful approaches for tissue engineering application: electrospinning to fabricate a nanofibrous polymeric scaffold and pulsed laser deposition to tune and control the composition and morphology of the scaffold surface. A multi-component scaffold composed of synthetic and natural polymers was proposed to combine the biocompatibility and suitable mechanical properties of poly(D,L-lactic acid) with the hydrophilicity and cellular affinity of gelatin. As part of a biomimetic strategy for the generation of bi-functional scaffolds, we coated the electrospun fibers with a thin film of a bioactive glass–ceramic material supplemented with manganese ions. The physico-chemical properties and composition of the bi-layered scaffold were investigated, and its bioactivity, in terms of induced mineralization, was tested by incubation in a simulated body fluid buffer. The processes of the inorganic film dissolution and the calcium phosphate phases growth were followed by microscopic and spectroscopic techniques, confirming that a combination of bioactive glass–ceramics and nanofibrous scaffolds has promising potential in the regeneration of osteochondral tissue due to its ability to induce mineralization in connective tissues.

Details

ISSN :
20796412
Volume :
12
Database :
OpenAIRE
Journal :
Coatings
Accession number :
edsair.doi.dedup.....8eb471710aaa02531de3ba2de3fe0bab
Full Text :
https://doi.org/10.3390/coatings12101427