Back to Search
Start Over
YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage
- Source :
- Bioessays
- Publication Year :
- 2016
-
Abstract
- The YAP/TAZ family of transcriptional co-activators drives cell proliferation in epithelial tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear. Here we review recent reports that YAP and TAZ act primarily as sensors of epithelial cell polarity, being inhibited when cells differentiate an apical membrane domain, and being activated when cells contact the extracellular matrix via their basal membrane domain. Apical signalling occurs via the canonical Crumbs/CRB-Hippo/MST-Warts/LATS kinase cascade to phosphorylate and inhibit YAP/TAZ. Basal signalling occurs via Integrins and Src family kinases to phosphorylate and activate YAP/TAZ. Thus, YAP/TAZ is localised to the nucleus in basal stem/progenitor cells and cytoplasm in differentiated squamous cells or columnar cells. In addition, other signals such as mechanical forces, tissue damage and possibly receptor tyrosine kinases (RTKs) can influence MST-LATS or Src family kinase activity to modulate YAP/TAZ activity.
- Subjects :
- 0301 basic medicine
TAZ
Hippo pathway
Integrin
Cell Cycle Proteins
wound healing
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
Receptor tyrosine kinase
Epithelium
03 medical and health sciences
Cell polarity
cancer
Animals
Drosophila Proteins
Humans
Src family kinase
epithelial polarity
development
Epithelial polarity
mechanotransduction
Hippo signaling pathway
biology
Stem Cells
Review Essays
Cell Polarity
Nuclear Proteins
RNA-Binding Proteins
YAP-Signaling Proteins
Apical membrane
Cell biology
Biomechanical Phenomena
Repressor Proteins
Phosphotransferases (Alcohol Group Acceptor)
030104 developmental biology
Prospects & Overviews
biology.protein
Trans-Activators
mechanosensing
YAP
Stem cell
biological
Signal Transduction
Transcription Factors
Subjects
Details
- ISSN :
- 15211878 and 02659247
- Volume :
- 38
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- BioEssays : news and reviews in molecular, cellular and developmental biology
- Accession number :
- edsair.doi.dedup.....8ea4352ea63969dcf0e143216898559d