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The Effect of Lipopolysaccharide on Ischemic-Reperfusion Injury of Heart: A Double Hit Model of Myocardial Ischemia and Endotoxemia
- Source :
- Journal of Cardiovascular and Thoracic Research, Vol 7, Iss 3, Pp 81-86 (2015), Journal of Cardiovascular and Thoracic Research
- Publication Year :
- 2015
- Publisher :
- Tabriz University of Medical Sciences, 2015.
-
Abstract
- Introduction: Myocardial ischemia may coincide and interact with sepsis and inflammation. Our objective was to examine the effects of bacterial endotoxin on myocardial functions and cell injury during acute ischemia. Methods: Rabbits were pretreated with incremental doses of E. Coli lipopolysaccharide (LPS) or normal saline. Myocardial ischemia was induced by 50-minute occlusion of left anterior descending artery. S-TNFaR was additionally used to block the effects LPS. Results: Ventricular contractility as it was measured by dp/dt during systole decreased from 2445± 1298 to 1422 ± 944 mm Hg/s, P = .019. Isovolumetric relaxation time as an index of diastolic function was prolonged from 50±18 ms to 102± 64 ms following ischemia. Pretreatment with low concentrations of LPS (
- Subjects :
- medicine.medical_specialty
Tumor Necrosis Factor-Alpha
lcsh:Diseases of the circulatory (Cardiovascular) system
business.industry
Ischemia
medicine.disease
Endotoxemia
Sepsis
Contractility
Myocardium Ischemia
medicine.anatomical_structure
lcsh:RC666-701
Anesthesia
Internal medicine
Reperfusion Injury
Cardiology
medicine
Tumor necrosis factor alpha
Original Article
Systole
Cardiology and Cardiovascular Medicine
business
Isovolumetric contraction
Reperfusion injury
Artery
Subjects
Details
- Language :
- English
- ISSN :
- 20086830 and 20085117
- Volume :
- 7
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular and Thoracic Research
- Accession number :
- edsair.doi.dedup.....8e9b7511907823c306d90b19730f10a8