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Decreased expression of calcium receptor in parathyroid tissue in patients with hyperparathyroidism secondary to chronic renal failure
- Source :
- Endocrine pathology. 14(1)
- Publication Year :
- 2003
-
Abstract
- The response of parathyroid cells to serum calcium is regulated by a calcium-sensing receptor protein (CaR). In patients with chronic renal failure, hypocalcemia contributes to the parathyroid hyperplasia and increased parathyroid hormone secretion characteristic of secondary hyperparathyroidism (sHPT). However, patients with uremia also display reduced sensitivity to extracellular calcium; this seems to be owing to an alteration of the receptor mechanism. This study examined calcium receptor expression in the parathyroid tissue of patients with sHPT, using immunohistochemical techniques and comparison with normal tissue and parathyroid glands of patients with primary hyperparathyroidism. In all the glands studied, immunostaining was more intense in chief cells than in oxyphilic, transitional, and clear cells. The parathyroid glands of patients with sHPT displayed significantly reduced expression of CaR with respect to morphologically normal ones; a very similar reduction is reported in adenomas. Furthermore, in glands displaying multinodular hyperplasia, expression was less marked in nodule-forming cells than in internodular areas. The decreased expression of calcium receptors in the parathyroid tissue of uremic patients was thought to be owing to the different cell populations present; these parathyroid glands contained predominantly transitional, oxyphilic, and clear cells, which normally express fewer receptors than chief cells, which are more abundant in normal glands.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Receptor expression
Pathology and Forensic Medicine
Parathyroid Glands
Endocrinology
Internal medicine
medicine
Humans
Uremia
Calcium metabolism
Hyperparathyroidism
business.industry
Calcium-Binding Proteins
General Medicine
Parathyroid chief cell
medicine.disease
Immunohistochemistry
Parathyroid hormone secretion
Kidney Failure, Chronic
Secondary hyperparathyroidism
Calcium
Female
Hyperparathyroidism, Secondary
Calcium-sensing receptor
business
Primary hyperparathyroidism
Subjects
Details
- ISSN :
- 10463976
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Endocrine pathology
- Accession number :
- edsair.doi.dedup.....8e99730daa992857c9c706448cff88c3