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The clinical significance of karyotype in acute myelogenous leukemia
- Source :
- Cancer Genetics and Cytogenetics. 40:203-216
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- To evaluate further the prognostic significance of karyotype at diagnosis of acute myelogenous leukemia (AML), we have made a follow-up study of 711 patients who were diagnosed between January 1, 1980, and March 31, 1982, and who were originally reported by the Fourth International Workshop on Chromosomes in Leukemia (4IWCL). Three different chromosomal classifications were evaluated, including presence of normal and abnormal metaphases (NN-AN-AA classification), a modification of the Chicago classification, and a complexity classification. All three chromosomal classifications were shown to correlate significantly with outcome in patients with de novo AML. Furthermore, the NN-AN-AA classification and the complexity classification had independent prognostic significance when age, sex, and FAB morphology were also considered in multivariate analyses of survival. These data provide further evidence that karyotype is an important factor in predicting the outcome of patients with AML.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
Myeloid
Adolescent
Biology
Myelogenous
Internal medicine
Genetics
medicine
Humans
Clinical significance
In patient
Child
Molecular Biology
Aged
Aged, 80 and over
Chromosome Aberrations
Follow up studies
Infant
Karyotype
Middle Aged
Prognosis
medicine.disease
Leukemia, Myeloid, Acute
Leukemia
medicine.anatomical_structure
Child, Preschool
Karyotyping
Immunology
Female
Follow-Up Studies
Subjects
Details
- ISSN :
- 01654608
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Cancer Genetics and Cytogenetics
- Accession number :
- edsair.doi.dedup.....8e990b3be2a588befa642fca4521cd43