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Genome Editing and Its Applications in Model Organisms
- Source :
- Genomics, Proteomics & Bioinformatics, Genomics, Proteomics & Bioinformatics, Vol 13, Iss 6, Pp 336-344 (2015)
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- Technological advances are important for innovative biological research. Development of molecular tools for DNA manipulation, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas), has revolutionized genome editing. These approaches can be used to develop potential therapeutic strategies to effectively treat heritable diseases. In the last few years, substantial progress has been made in CRISPR/Cas technology, including technical improvements and wide application in many model systems. This review describes recent advancements in genome editing with a particular focus on CRISPR/Cas, covering the underlying principles, technological optimization, and its application in zebrafish and other model organisms, disease modeling, and gene therapy used for personalized medicine.
- Subjects :
- ved/biology.organism_classification_rank.species
Computational biology
Review
Biology
Genome
Biochemistry
Models, Biological
CRISPR/Cas
Gene therapy
Genome editing
Genetics
CRISPR
Animals
Humans
Clustered Regularly Interspaced Short Palindromic Repeats
Model organism
Molecular Biology
lcsh:QH301-705.5
Zebrafish
Zinc finger
Transcription activator-like effector nuclease
Deoxyribonucleases
business.industry
ved/biology
Disease model
Zinc Fingers
Genetic Therapy
Zinc finger nuclease
Computational Mathematics
lcsh:Biology (General)
Mutagenesis
Personalized medicine
CRISPR-Cas Systems
business
Genetic Engineering
Subjects
Details
- Language :
- English
- ISSN :
- 22103244 and 16720229
- Volume :
- 13
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Genomics, Proteomics & Bioinformatics
- Accession number :
- edsair.doi.dedup.....8e97247a51e0f9f45b4224b96268fd88