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Characteristics of New Peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as Inhibitors of Enzymes Involved in Metabolic Syndrome and Antimicrobial Potential
- Source :
- Molecules, Molecules, Vol 25, Iss 2492, p 2492 (2020), Volume 25, Issue 11
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- The aim of this study was to determine the cytotoxic properties, influence on enzyme activity involved in metabolic syndrome, and antimicrobial activity of synthetic peptides with GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT sequences. Peptides have no cytotoxic effect on cells. The highest inhibitory effect on angiotensin converting enzyme I was noted for peptide GT-14 (IC50 = 525.63 &micro<br />g/mL). None of the tested peptides had an influence on &alpha<br />glucosidase. The highest &alpha<br />amylase and lipase inhibitory activity was noted for GG-12 (IC50 = 56.72 and 60.62 &micro<br />g/mL, respectively). The highest lipoxidase inhibitory activity was determined for peptide ER-13 (IC50 = 84.35 &micro<br />g/mL). Peptide RQ-9 was characterized by the highest COX inhibitory activity (0.31 and 4.77 &micro<br />g/mL for COX-1 and COX-2, respectively). Only peptide RQ-9 inhibited S. enteritidis ATCC 4931 growth (42%&ndash<br />48%) in all tested concentrations (15.62&ndash<br />250 mg/mL).
- Subjects :
- Pharmaceutical Science
Peptide
Inhibitory postsynaptic potential
Article
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
0404 agricultural biotechnology
lcsh:Organic chemistry
Anti-Infective Agents
Drug Discovery
Cytotoxic T cell
Physical and Theoretical Chemistry
Lipase
inhibitory
IC50
030304 developmental biology
chemistry.chemical_classification
Metabolic Syndrome
0303 health sciences
antimicrobial activity
biology
Organic Chemistry
04 agricultural and veterinary sciences
Antimicrobial
040401 food science
Enzyme assay
Enzyme
chemistry
Biochemistry
Salmonella enteritidis
Chemistry (miscellaneous)
cytotoxic properties
biology.protein
peptides
Molecular Medicine
alpha-Amylases
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....8e941674bdddf5511af4a667eba60419