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The Anti-Inflammatory Effect of Guchangzhixie-Pill by Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in an Ulcerative Colitis Rat Model
- Source :
- Evidence-based Complementary and Alternative Medicine : eCAM, Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017)
- Publication Year :
- 2016
-
Abstract
- Ulcerative colitis (UC) is one of the major types of inflammatory bowel diseases (IBD). Abnormal colonic enterochromaffin (EC) cell hyperplasia and serotonin availability have been described in UC. Guchangzhixie-pill (GCZX-pill), a Chinese herbal formula composed of six herbs, is modified based on a traditional formula (Jiechangyan-pill) for inflammatory and ulcerative gastrointestinal disorders. This study aims to investigate the anti-inflammatory effect and the underlying mechanisms of GCZX-pill on trinitrobenzene sulfonic acid- (TNBS-) induced UC in rats. After orally administrating a GCZX-pill to UC rats for 14 days, the results of the inflammation evaluation, such as disease activity index (DAI), macroscopic score (MS), myeloperoxidase (MPO) activity, and other methods, suggested that the GCZX-pill showed remarkable anti-inflammatory results in UC rats. In addition, the abnormal EC cell numbers, colonic tryptophan hydroxylase (TPH) expression, and serotonin (5-HT) contents in TNBS-induced UC rats were significantly reduced by the GCZX-pill. This data demonstrates that the GCZX-pill can attenuate the inflammation in UC rats and the anti-inflammatory effect of the GCZX-pill may be medicated by reducing colonic EC cell hyperplasia and 5-HT availability.
- Subjects :
- medicine.medical_specialty
Article Subject
medicine.drug_class
Inflammation
Gastroenterology
Anti-inflammatory
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
biology
business.industry
lcsh:Other systems of medicine
Hyperplasia
Tryptophan hydroxylase
medicine.disease
lcsh:RZ201-999
Ulcerative colitis
digestive system diseases
Complementary and alternative medicine
030220 oncology & carcinogenesis
Myeloperoxidase
biology.protein
Enterochromaffin cell
030211 gastroenterology & hepatology
Serotonin
medicine.symptom
business
Research Article
Subjects
Details
- ISSN :
- 1741427X
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- Evidence-based complementary and alternative medicine : eCAM
- Accession number :
- edsair.doi.dedup.....8e8feaffc0c7928223af4c1fa741cd50