Back to Search
Start Over
Detection of QTL for Carcass Quality on Chromosome 6 by Exploiting Linkage and Linkage Disequilibrium in Hanwoo
- Source :
- Asian-Australasian Journal of Animal Sciences, Vol 25, Iss 1, Pp 17-21 (2012), Asian-Australasian Journal of Animal Sciences
- Publication Year :
- 2011
- Publisher :
- Asian Australasian Association of Animal Production Societies, 2011.
-
Abstract
- The purpose of this study was to improve mapping power and resolution for the QTL influencing carcass quality in Hanwoo, which was previously detected on the bovine chromosome (BTA) 6. A sample of 427 steers were chosen, which were the progeny from 45 Korean proven sires in the Hanwoo Improvement Center, Seosan, Korea. The samples were genotyped with the set of 2,535 SNPs on BTA6 that were imbedded in the Illumina bovine 50 k chip. A linkage disequilibrium variance component mapping (LDVCM) method, which exploited both linkage between sires and their steers and population-wide linkage disequilibrium, was applied to detect QTL for four carcass quality traits. Fifteen QTL were detected at 0.1% comparison-wise level, for which five, three, five, and two QTL were associated with carcass weight (CWT), backfat thickness (BFT), longissimus dorsi muscle area (LMA), and marbling score (Marb), respectively. The number of QTL was greater compared with our previous results, in which twelve QTL for carcass quality were detected on the BTA6 in the same population by applying other linkage disequilibrium mapping approaches. One QTL for LMA was detected on the distal region (110,285,672 to 110,633,096 bp) with the most significant evidence for linkage (p10(-5)). Another QTL that was detected on the proximal region (33,596,515 to 33,897,434 bp) was pleiotrophic, i.e. influencing CWT, BFT, and LMA. Our results suggest that the LDVCM is a good alternative method for QTL fine-mapping in detection and characterization of QTL.
- Subjects :
- Linkage (software)
Genetics
Linkage disequilibrium
education.field_of_study
QTL
Linkage Disequilibrium Mapping
Marbled meat
Population
lcsh:Animal biochemistry
SNP
Single-nucleotide polymorphism
Biology
Quantitative trait locus
Article
Linkage Disequilibrium
Hanwoo
Animal Science and Zoology
lcsh:Animal culture
education
lcsh:QP501-801
Carcass Trait
lcsh:SF1-1100
Food Science
Subjects
Details
- ISSN :
- 19765517 and 10112367
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Asian-Australasian Journal of Animal Sciences
- Accession number :
- edsair.doi.dedup.....8e8e3fec260618109273c146d3391465