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Impact of influenza syndrome and flu vaccine on survival of cancer patients during immunotherapy in the INVIDIa study

Impact of influenza syndrome and flu vaccine on survival of cancer patients during immunotherapy in the INVIDIa study

Authors :
Emmanuele De Luca
Francesca Mazzoni
Maria Giuseppa Vitale
Massimo Di Maio
Alessio Cortellini
Corrado Ficorella
Ugo De Giorgi
Francesco Atzori
Giuseppe Fornarini
Antonio Maestri
Sara Elena Rebuzzi
Melissa Bersanelli
Diana Giannarelli
Elena Verzoni
Silverio Tomao
Pietro Di Marino
Veronica Mollica
Roberto Sabbatini
Giovanni Schinzari
Sebastiano Buti
Mariella Sorarù
Michele De Tursi
Giuseppe Procopio
Sabrina Rossetti
Claudia Mucciarini
Pierangela Sepe
Teodoro Sava
Leonardo La Torre
Francesco Massari
Marcello Tiseo
Ernesto Rossi
Giuseppe Luigi Banna
Vanja Vaccaro
Stefano Panni
Valentino Martelli
Source :
Immunotherapy. 12(2)
Publication Year :
2020

Abstract

Aim: INVIDIa was a retrospective, multicenter study, exploring the clinical efficacy of influenza vaccine in 300 cancer patients undergoing immunotherapy. Overall survival (OS) was immature at the initial report. Methods: We reported the final OS analysis from the original study population and within subgroups. Results: Both at the univariate and multivariate analysis, the occurrence of influenza syndrome (IS) was significantly related to better OS in the overall population (OR: 0.53 [95% CI: 0.32–0.88]; p = 0.01). In the lung cancer subgroup, receiving flu vaccine and/or developing IS was related to better OS (p = 0.04). Within elderly patients, the flu vaccine was the main variable for the relative OS advantage (p = 0.05). Conclusion: Receiving the flu vaccine and/or developing IS was related to better OS within the INVIDIa population.

Details

ISSN :
17507448
Volume :
12
Issue :
2
Database :
OpenAIRE
Journal :
Immunotherapy
Accession number :
edsair.doi.dedup.....8e78ce235c8031e901a78afd0e03c6c1