Morphometry of dermal nerve fibers in human skin

{#article-title-2} “Morphometry of dermal nerve fibers in human skin”1 is the first comprehensive analysis of nerve fibers in both the dermal and the intraepidermal portions of 3-mm punch biopsies using widely available laboratory techniques. Expanding the analysis of skin biopsies to include dermal as well as intraepidermal regions might allow 1) examination of longer segments of axons in addition to measures of fiber density, 2) expansion of the range of axon types measured, including larger diameter fibers and axons that innervate mechanoreceptors and sweat glands, and 3) comparison of changes in the distal limb extreme axon terminals with those in more proximal regions. The report provides clear evidence that the assessment of dermal nerve fibers is feasible; it uses …