Back to Search
Start Over
Preventive effects of β-cryptoxanthin against cadmium-induced oxidative stress in the rat testis
- Source :
- Asian Journal of Andrology, Vol 18, Iss 6, Pp 920-924 (2016), Asian Journal of Andrology
- Publication Year :
- 2016
- Publisher :
- Wolters Kluwer Medknow Publications, 2016.
-
Abstract
- β-cryptoxanthin (CRY), a major carotenoid of potential interest for health, is obtained naturally from orange vegetables and fruits. A few research studies have reported that CRY could decrease oxidative stress and germ cell apoptosis. The purpose of this study was to examine the effects of CRY on acute cadmium chloride (CdCl 2 )-induced oxidative damage in rat testes. For this study, 24 rats were divided into four groups, one of which serves as a control group that received intraperitoneal (i.p.) injections of corn oil and physiological saline. The other rats were i.p. injected with CRY (10 μg kg-1 ) every 8 h, beginning 8 h before CdCl 2 (2.0 mg kg-1 ) treatment. The pathological and TUNEL findings revealed that CRY ameliorated the Cd-induced testicular histological changes and germ cell apoptosis in the rats. Furthermore, the Cd-induced decrease in the testicular testosterone (T) level was attenuated after CRY administration (P < 0.05). The administration of CRY significantly reversed the Cd-induced increases in the lipid peroxide (LPO) and malondialdehyde (MDA) levels (P < 0.01). The testicular antioxidants superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were decreased by treatment with Cd alone but were restored by CRY co-treatment. These results demonstrated that the application of CRY can enhance the tolerance of rats to Cd-induced oxidative damage and suggest that it has promised as a pharmacological agent to protect against Cd-induced testicular toxicity.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
endocrine system
Urology
Beta-Cryptoxanthin
010501 environmental sciences
Cadmium chloride
medicine.disease_cause
lcsh:RC870-923
01 natural sciences
Antioxidants
Superoxide dismutase
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
testicular damage
Internal medicine
Malondialdehyde
apoptosis
cadmium chloride
cryptoxanthin
oxidative stress
rat
testosterone
Testis
medicine
Animals
0105 earth and related environmental sciences
biology
Lipid peroxide
Superoxide Dismutase
General Medicine
Glutathione
Catalase
lcsh:Diseases of the genitourinary system. Urology
Rats
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
biology.protein
Original Article
Corn oil
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 17457262
- Volume :
- 18
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Andrology
- Accession number :
- edsair.doi.dedup.....8e622df586b3ecf89576c2e9c19b701a