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Direct comparison of dietary portfolio vs statin on C-reactive protein
- Source :
- European Journal of Clinical Nutrition
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- Background: 3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known. Objective: To compare the efficacy of a dietary combination (portfolio) of cholesterol-lowering foods vs a statin in reducing C-reactive protein (CRP) as a biomarker of inflammation linked to increased cardiovascular disease risk. Methods: In all, 34 hyperlipidemic subjects completed three 1-month treatments as outpatients in random order: a very low-saturated fat diet (control); the same diet with 20 mg lovastatin (statin); and a diet high in plant sterols (1.0 g/1000 kcal), soy protein (21.4 g/1000 kcal), viscous fibers (9.8 g/1000 kcal), and almonds (14 g/1000 kcal) (portfolio). Fasting blood samples were obtained at weeks 0, 2, and 4. Results: Using the complete data, no treatment reduced serum CRP. However, when subjects with CRP levels above the 75th percentile for previously reported studies (>3.5 mg/l) were excluded, CRP was reduced similarly on both statin, −16.3±6.7% (n=23, P=0.013) and dietary portfolio, −23.8±6.9% (n=25, P=0.001) but not the control, 15.3±13.6% (n=28, P=0.907). The percentage CRP change from baseline on the portfolio treatment (n=25) was greater than the control (n=28, P=0.004) but similar to statin treatment (n=23, P=0.349). Both statin and portfolio treatments were similar in reducing CRP and numerically more effective than control but only the change in portfolio was significant after the Bonferroni adjustment. Conclusions: A combination of cholesterol-lowering foods reduced C-reactive protein to a similar extent as the starting dose of a first-generation statin.
- Subjects :
- Adult
Male
medicine.medical_specialty
Statin
medicine.drug_class
Diet therapy
Saturated fat
Medicine (miscellaneous)
Hyperlipidemias
soy protein
030204 cardiovascular system & hematology
Article
plant sterols
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
030212 general & internal medicine
Diet, Fat-Restricted
Aged
Inflammation
Nutrition and Dietetics
national cholesterol education program diet
biology
business.industry
Cholesterol
C-reactive protein
almonds
Middle Aged
low saturated fat
3. Good health
C-Reactive Protein
Endocrinology
chemistry
Cardiovascular Diseases
viscous dietary fiber
Saturated fatty acid
biology.protein
Female
Lovastatin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Biomarkers
medicine.drug
Lipoprotein
Subjects
Details
- ISSN :
- 14765640 and 09543007
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....8e5fb08dad9863a15f2703d831d9b126