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Are Migraine Patients at Increased Risk for Symptomatic Coronavirus Disease 2019 Due to Shared Comorbidities?
- Source :
- Headache: The Journal of Head and Face Pain
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- WOS:000583303300001 PubMed ID: 33124044 The coronavirus disease 2019 (COVID-19) pandemic has rapidly transformed the whole world and forced us to look through comorbid diseases and risk factors from a different perspective. COVID-19 shows some inherent risk factors like cardiovascular comorbidities independent from age, gender, and geographic location. One of the most peculiar features of the COVID-19 pandemic is that severe acute respiratory syndrome coronavirus 2 respiratory infections disproportionately impact patients with hypertension, diabetes, and other cardiovascular comorbidities rather than those with allergic respiratory diseases and immune-compromised conditions. Migraine is a complex neuro-vasculo-inflammatory disorder that is also packed frequently with certain medical conditions including vascular disorders, hypertension, allergic diseases such as asthma and systemic inflammatory disorders. Accordingly, 2 different questions arise during the pandemic: (1) Do share comorbidities of cardiovascular diseases and hypertension increase the risk of symptomatic COVID-19 for migraine patients? (2) Do comorbid allergic and atopic diseases, including asthma act as opposite influencers alongside with female gender? This paper focuses on the co-existence of comorbidities of COVID-19, in comparison with migraine, based on a wide clinical dataset and available reports. Discussed mechanisms include potential strategic roles of angiotensin-converting enzyme 2, angiotensin-II, and nucleotide oligomerization domain-like receptor family, pyrin domain containing 3 inflammasome, playing remarkable parts in the pathogenesis of COVID-19 and migraine. There are also some clues about the importance of endothelial and pericyte dysfunction and neuroinflammation in COVID-19 infection, related to complications and survival of the patients. The large epidemiological studies as well as basic research, focusing on migraine patients with COVID-19 will clarify these vital questions during the upcoming periods. Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences; Gazi UniversityGazi University; Istanbul UniversityIstanbul University The authors would like to thank Dr. Didem Derici Yildirim for re-analizing the data and producing Figure 1. The study partially supported by Turkish Academy of Sciences (TUBA), and Gazi University and Istanbul University Research Projects.
- Subjects :
- medicine.medical_specialty
Migraine Disorders
Clinical Neurology
Comorbidity
nucleotide oligomerization domain‐
Pyrin domain
pericytes
comorbid disorders
03 medical and health sciences
coronavirus disease 2019
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
Inherent risk
like receptor family
Epidemiology
Pandemic
medicine
Hypersensitivity
Prevalence
Humans
migraine
030212 general & internal medicine
Vascular Diseases
Asthma
business.industry
SARS-CoV-2
COVID-19
medicine.disease
Neurology
Migraine
Neurology (clinical)
business
030217 neurology & neurosurgery
pyrin domain containing 3 inflammasome
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Headache: The Journal of Head and Face Pain
- Accession number :
- edsair.doi.dedup.....8e590c37e3c7b4092212a829dcd6bb55
- Full Text :
- https://doi.org/10.1111/head.13998