Back to Search
Start Over
Effectiveness of cyanoacrylate microbial sealant in the reduction of surgical site infection in gynecologic oncology procedures: A phase III single institution prospective randomized trial
- Source :
- Gynecologic Oncology. 144:193-199
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Objectives Surgery is a cornerstone for patients with gynecologic malignancies. Surgical site infections (SSI) remain a source of post-operative morbidity. Consequences range from escalated costs, delay in adjuvant therapy, and increased morbidity. Our primary objective was to evaluate the effectiveness of a cyanoacrylate microbial sealant (CMS) to reduce post-operative SSI following laparotomy for suspected gynecologic malignancy. Methods Patients were randomized using a 1:1 allocation to receive either standard skin preparation or standard preparation with CMS and stratified by BMI. Patients were followed for 6weeks for SSI. Demographic data was collected through the EMR. Associations between SSI, use of CMS, and clinicopathologic factors were explored using descriptive statistics, chi-square and multivariate analysis. Results 300 patients underwent randomization. Median age of the cohort was 58. Arms were matched and there was no difference in rate of medical comorbidities. Mean BMI was 38.8kg/m 2 in patients randomized to BMI≥30 and 26.3kg/m 2 randomized to BMI p =0.18). Multivariate model demonstrated that BMI≥30 ( p p =0.010), transfusion in the OR ( p p =0.0005) were associated with post-operative SSI. Conclusions Patients presenting to a gynecologic oncologist for surgery frequently present with multiple risk factors for SSI and laparotomy is complicated by surgical-site complications in up to 30% of cases. The addition of CMS alone does not appear to reduce risk of overall SSI. Additional risk-reducing strategies including use of antimicrobial agents and optimization of modifiable risk factors prior to surgery should be explored as pathways for reducing this significant post-operative morbidity.
- Subjects :
- Adult
medicine.medical_specialty
Multivariate analysis
Randomization
Genital Neoplasms, Female
medicine.medical_treatment
Gynecologic oncology
030501 epidemiology
law.invention
Young Adult
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Risk Factors
law
Laparotomy
Preoperative Care
Adjuvant therapy
medicine
Humans
Surgical Wound Infection
Cyanoacrylates
Prospective Studies
Aged
Aged, 80 and over
business.industry
Chlorhexidine
Obstetrics and Gynecology
Middle Aged
Anti-Bacterial Agents
Surgery
Oncology
030220 oncology & carcinogenesis
Cohort
Anti-Infective Agents, Local
Female
0305 other medical science
business
Gynecologic Oncologist
Subjects
Details
- ISSN :
- 00908258
- Volume :
- 144
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....8e58338f6835d01101d0ee710b908b49