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High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil
- Source :
- Immunogenetics. 70(6)
- Publication Year :
- 2017
-
Abstract
- Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil. A total of 1560 individuals were genotyped for polymorphisms in DC-SIGN (rs4804803), FcγRIIa (rs1801274), VDR (rs7975232), and TNF-α (rs1800629). The presence of anti-dengue antibodies (IgM and/or IgG) in these samples was also assayed. Anti-dengue antibodies were detected at an overall frequency of 16.86%, indicating a virus infection in asymptomatic individuals. The genotypic frequencies of all SNPs studied did not differ between the asymptomatic and control groups. Regarding the allelic frequencies of the four SNPs analyzed, a higher frequency was detected of the G allele of FcγRIIa/rs1801274 in the asymptomatic individuals when compared to that in the control group (p = 0.03). Therefore, the results showed a high prevalence of asymptomatic individuals in Minas Gerais State, with a potential association between the presence of the G allele of FcγRIIa/rs1801274 and protection against symptomatic disease.
- Subjects :
- 0301 basic medicine
Adult
Male
030231 tropical medicine
Immunology
Population
Single-nucleotide polymorphism
Receptors, Cell Surface
Arginine
Asymptomatic
Polymorphism, Single Nucleotide
Virus
Dengue fever
Dengue
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Genotype
Genetics
medicine
Prevalence
Humans
Genetic Predisposition to Disease
Lectins, C-Type
Allele
education
Genetic Association Studies
education.field_of_study
biology
Tumor Necrosis Factor-alpha
Receptors, IgG
Middle Aged
medicine.disease
Virology
030104 developmental biology
biology.protein
Receptors, Calcitriol
Female
Antibody
medicine.symptom
Cell Adhesion Molecules
Brazil
Subjects
Details
- ISSN :
- 14321211
- Volume :
- 70
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Immunogenetics
- Accession number :
- edsair.doi.dedup.....8e54389d1fa5dc98bc46a0f0f906cc22