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Seprafilm superior to Gore-Tex in the prevention of peridural fibrosis
- Source :
- Scopus-Elsevier
- Publication Year :
- 2004
- Publisher :
- Journal of Neurosurgery Publishing Group (JNSPG), 2004.
-
Abstract
- Object.This is an investigation into the effects of two barrier membranes in the prevention of peridural fibrosis in an animal model.Methods.Seprafilm or Gore-Tex was applied to a laminectomy defect overlying the dura mater in rats separated into treatment groups. A third group of rats underwent laminectomy only and served as controls. Two months postoperatively a histological study was performed to compare the amount of scar tissue in each group.The gross dissection demonstrated that both membranes created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the amount of tissue adhering to the dura mater. Statistically, Seprafilm was superior to Gore-Tex in preventing peridural fibrosis (p < 0.05).Conclusions.Seprafilm can prevent peridural fibrosis better than Gore-Tex and can be used in humans in spinal surgery.
- Subjects :
- Epidural Space
Male
medicine.medical_specialty
Peridural fibrosis
Dura mater
medicine.medical_treatment
Adhesion (medicine)
Biocompatible Materials
Dissection (medical)
Cicatrix
Postoperative Complications
Animal model
Fibrosis
medicine
Animals
Hyaluronic Acid
Rats, Wistar
Polytetrafluoroethylene
business.industry
Laminectomy
medicine.disease
Epidural space
Rats
Surgery
medicine.anatomical_structure
Dura Mater
business
Subjects
Details
- ISSN :
- 00223085
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Journal of Neurosurgery
- Accession number :
- edsair.doi.dedup.....8e4a344a6325e72d679da193bef6d66b