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Tobramycin sulfate elimination in premature infants
- Source :
- The Journal of Pediatrics. 103:131-135
- Publication Year :
- 1983
- Publisher :
- Elsevier BV, 1983.
-
Abstract
- The elimination pharmacokinetics of tobramycin sulfate was studied in 25 newborn infants of birth weight 0.7 to 4.7 kg during 31 treatment episodes. The peak serum concentrations after a 2.5 mg/kg dose were usually within the therapeutic range of 5 to 10 micrograms/ml; however, the serum predose trough values were elevated above the theoretical safe limit of 2 micrograms/ml. Because of the prolonged serum elimination half-lives, a calculated extended dosage interval, sometimes greater than 24 hours, was necessary to obtain a predose trough of less than or equal to 2 micrograms/ml. The serum elimination half-lives inversely correlated with gestational age, extrauterine age, birth weight, and creatinine clearance. The very low ratio of tobramycin renal clearance to creatinine renal clearance was virtually constant and indicated a probable tubular reabsorption of tobramycin. A general dosage schedule based on birth weight was derived from the data. An alternative formula was derived to enable prediction of the tobramycin elimination half-life based on a combination of birth weight, gestational age, and extrauterine age for an infant younger than 7 days of age.
- Subjects :
- medicine.medical_specialty
Birth weight
Physiology
Renal function
Infant, Premature, Diseases
Kidney
Drug Administration Schedule
Therapeutic index
Pharmacokinetics
medicine
Tobramycin
Humans
business.industry
Infant, Newborn
Gestational age
Bacterial Infections
Infant, Low Birth Weight
Tobramycin Sulfate
Anti-Bacterial Agents
Surgery
Kinetics
Renal physiology
Pediatrics, Perinatology and Child Health
business
Half-Life
medicine.drug
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....8e377c126ecdc9a80755bf91b7abae83
- Full Text :
- https://doi.org/10.1016/s0022-3476(83)80799-9