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Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue
- Source :
- Br J Pharmacol
- Publication Year :
- 2018
-
Abstract
- A vital role of adrenoceptors in metabolism and energy balance has been well documented in the heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of the mechanistic target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1 and 2 as a novel paradigm of adrenoceptor signalling in the heart, skeletal muscle, and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions. LINKED ARTICLES: This article is part of a themed section on Adrenoceptors-New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.
- Subjects :
- 0301 basic medicine
Adipose tissue
mTORC1
mTORC2
Themed Section: Review Articles
Muscle hypertrophy
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Muscle, Skeletal
Mechanistic target of rapamycin
PI3K/AKT/mTOR pathway
Pharmacology
Sirolimus
biology
Skeletal muscle
Adrenergic beta-Agonists
Cell biology
030104 developmental biology
medicine.anatomical_structure
Adipose Tissue
biology.protein
030217 neurology & neurosurgery
GLUT4
Subjects
Details
- ISSN :
- 14765381
- Volume :
- 176
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- British journal of pharmacology
- Accession number :
- edsair.doi.dedup.....8e363d94fb00dfe9535e714e5a4f6c22