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A genome-wide association study of energy intake and expenditure
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 8, p e0201555 (2018)
- Publication Year :
- 2018
- Publisher :
- Public Library of Science, 2018.
-
Abstract
- Excessive energy intake or insufficient energy expenditure, which result in energy imbalance, contribute to the development of obesity. Obesity-related genes, such as FTO, are associated with energy traits. No genome-wide association studies (GWAS) have been conducted to detect the genetic associations with energy-related traits, including energy intake and energy expenditure, among European-ancestry populations. In this study, we conducted a genome-wide study using pooled GWAS including 12,030 European-ancestry women and 6,743 European-ancestry men to identify genetic variants associated with these two energy traits. We observed a statistically significant genome-wide SNP heritability for energy intake of 6.05% (95%CI = (1.76, 10.34), P = 0.006); the SNP heritability for expenditure was not statistically significantly greater than zero. We discovered three SNPs on chromosome 12q13 near gene ANKRD33 that were genome-wide significantly associated with increased total energy intake among all men. We also identified signals on region 2q22 that were associated with energy expenditure among lean people. Body mass index related SNPs were found to be significantly associated with energy intake and expenditure through SNP set analyses. Larger GWAS studies of total energy traits are warranted to explore the genetic basis of energy intake, including possible differences between men and women, and the association between total energy intake and other downstream phenotypes, such as diabetes and chronic diseases.
- Subjects :
- 0301 basic medicine
Male
Bioenergetics
Physiology
lcsh:Medicine
Genome-wide association study
030105 genetics & heredity
Biochemistry
Body Mass Index
Mathematical and Statistical Techniques
Medicine and Health Sciences
Public and Occupational Health
lcsh:Science
2. Zero hunger
Multidisciplinary
Genomics
Middle Aged
3. Good health
Physiological Parameters
Chromosomes, Human, Pair 2
Physical Sciences
Female
Statistics (Mathematics)
Research Article
Genotype
Single-nucleotide polymorphism
Biology
Research and Analysis Methods
Polymorphism, Single Nucleotide
White People
Molecular Genetics
03 medical and health sciences
medicine
Genome-Wide Association Studies
Genetics
SNP
Humans
Obesity
Statistical Methods
Molecular Biology
Genetic association
Chromosomes, Human, Pair 12
lcsh:R
Body Weight
Biology and Life Sciences
Computational Biology
Human Genetics
Physical Activity
Heritability
medicine.disease
Genome Analysis
030104 developmental biology
lcsh:Q
Energy Intake
Energy Metabolism
Body mass index
Mathematics
Demography
Meta-Analysis
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....8e3514e0ddcfd99e1cbe6fc41654dcd4