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In vivo evidence of role of bone morphogenetic protein-4 in the mouse ovary
- Source :
- Animal reproduction science. 106(3-4)
- Publication Year :
- 2006
-
Abstract
- The transition of a primordial follicle to a primary follicle is an early step in folliculogenesis. All female mammals are born with a fixed stock of primordial follicles, and exhaustion of that stock leads to menopause or infertility. Recently, several in vitro studies have indicated that BMP-4, BMP-7, and several other growth factors affect the transition of primordial to primary follicles. The aim of our present study was to investigate role of BMP-4 in this process using passive immunization to investigate the role of BMP-4 in a prepubertal mouse model. After seven days of treatment, the weight of antiBMP-4 treated ovaries was significantly lower than the ovaries from mice treated with nonimmune Ig. The number of primary follicles was lower, and the numbers of primordial follicles were higher in antiBMP-4 treated ovaries compared to control ovaries. Treatment with equine chorionic gonadotrophin (eCG) showed no influence on the effects of antiBMP-4 in the mouse ovary. Thus, the results of our study indicate that in vivo BMP-4 acts as transition factor in transition of primordial to primary follicle.
- Subjects :
- Infertility
medicine.medical_specialty
Gonadotropins, Equine
Injections, Subcutaneous
Bone Morphogenetic Protein 4
Bone morphogenetic protein
Antibodies
Mice
Endocrinology
Food Animals
Ovarian Follicle
In vivo
Internal medicine
medicine
Animals
Ovarian follicle
biology
Ovary
General Medicine
Organ Size
medicine.disease
Menopause
medicine.anatomical_structure
Bone morphogenetic protein 4
Bone Morphogenetic Proteins
biology.protein
Animal Science and Zoology
Female
Folliculogenesis
Antibody
Subjects
Details
- ISSN :
- 03784320
- Volume :
- 106
- Issue :
- 3-4
- Database :
- OpenAIRE
- Journal :
- Animal reproduction science
- Accession number :
- edsair.doi.dedup.....8e2f6e53444a4f734a7b2e40be558378