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Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment
- Source :
- Oncoimmunology, article-version (VoR) Version of Record, OncoImmunology, Vol 10, Iss 1 (2021)
- Publication Year :
- 2021
-
Abstract
- Exosomes are extracellular vesicles released from numerous types of cells that are involved in multiple tumors development. Exosomes contribute to the modulation of tumor microenvironment (TME) through intercellular communication. As essential immune stromal cells in the TME, tumor-associated macrophages (TAMs) participate in tumor development by mediating angiogenesis, metastasis, chemoresistance, and immune escape. Due to communication with multiple cells in the TME, they exhibit plasticity and heterogeneity during the progress of polarization from monocytes to macrophages. Previous studies suggest that targeting TAMs is a promising therapeutic strategy; however, the detailed mechanism by which TAMs regulate tumor development still remains unclear. In this review, we provide an overview of the roles of exosomes as messengers in the communication between tumor cells and polarization of TAMs; we also describe the effects of their interaction on tumor development. Finally, we comprehensively discussed the potential application of exosomes as the promising tumor immunotherapy strategy.
- Subjects :
- 0301 basic medicine
Stromal cell
Angiogenesis
medicine.medical_treatment
Immunology
cellular communication
Review
Biology
Exosomes
Exosome
Metastasis
03 medical and health sciences
0302 clinical medicine
Immune system
Neoplasms
Tumor-Associated Macrophages
medicine
Tumor Microenvironment
Immunology and Allergy
Humans
RC254-282
Tumor microenvironment
polarization
Macrophages
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunotherapy
RC581-607
medicine.disease
Microvesicles
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cancer research
Immunologic diseases. Allergy
Subjects
Details
- ISSN :
- 2162402X
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Oncoimmunology
- Accession number :
- edsair.doi.dedup.....8e2d8a40e0919f9df5da60ab901f0256