Validity of doubly labeled water in obese subjects: questioning the validity of any technique requires an indisputable accuracy of the reference method

to the editor: In a recent article, Guidotti et al. ([5][1]) reported that the nutritional and body adiposity status affects the dilution space ratio (Nd/No) between deuterium (2H) and 18O and validity of CO2 production (rCO2) by the doubly labeled water (DLW) method in mice. Their data disagree