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Reduced eosinophil apoptosis in induced sputum correlates with asthma severity
- Source :
- European Respiratory Journal. 22:484-490
- Publication Year :
- 2003
- Publisher :
- European Respiratory Society (ERS), 2003.
-
Abstract
- This study was carried out to investigate the relationship between induced sputum eosinophil apoptosis and clinical severity score, airway obstruction and symptom scores in patients with chronic stable asthma. Altogether, 41 chronic stable asthmatic subjects of varying severity defined by Aas score and 17 control subjects underwent spirometry, symptom questionnaire and successful sputum induction. Sputum was processed and cytospins prepared for light microscopy to determine normal and apoptotic eosinophils. Mild asthmatic subjects had a significantly lower percentage sputum eosinophils and a significantly higher eosinophil apoptotic ratio (AR) than moderate or chronic severe asthmatics. Severe asthmatic subjects had a significantly greater age, duration of asthma and sputum eosinophil count x mL(-1) than mild asthmatic subjects. Asthmatic subjects' symptom scores, severity scores and age inversely correlated with AR and the percentage of sputum eosinophils. Baseline forced expiratory volume in one second inversely correlated with percentage sputum eosinophils and positively correlated with AR. The study demonstrates a relationship between reduced sputum eosinophil apoptosis and increased clinical severity of chronic stable asthma, providing additional evidence that eosinophil apoptosis may be important in the resolution of eosinophilic airway inflammation in asthma.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
Spirometry
Sputum Cytology
Apoptosis
Severity of Illness Index
Allergic inflammation
Leukocyte Count
Random Allocation
Severity of illness
Humans
Medicine
Aged
Asthma
medicine.diagnostic_test
business.industry
Sputum
Middle Aged
respiratory system
Airway obstruction
Eosinophil
medicine.disease
respiratory tract diseases
Eosinophils
Cross-Sectional Studies
medicine.anatomical_structure
Case-Control Studies
Chronic Disease
Immunology
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 13993003 and 09031936
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal
- Accession number :
- edsair.doi.dedup.....8e1f9c592fd9d8a700c77301f9119cbf