Back to Search
Start Over
Depression and mortality after craniotomy for brain tumor removal: A Nationwide cohort study in South Korea
- Source :
- Journal of Affective Disorders. 295:291-297
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background We aimed to investigate the prevalence and associated factors of newly developed depression in patients who underwent craniotomy for brain tumor removal, as well as its effect on long-term mortality. Methods Using a nationwide cohort database in South Korea, we included adult patients diagnosed with brain tumors who underwent craniotomy for brain tumor removal from January 1, 2011, to December 31, 2017. We excluded patients with a preoperative history of depression. Results Among 4,275 patients, 727 (17.0%) patients were newly diagnosed with depression within one year, postoperatively. Two-year all-cause mortality and mortality due to brain cancer occurred in 1,233 (28.8%) and 1,099 (25.7%) patients, respectively. In the multivariable logistic regression model, older age, living in rural areas, newly acquired brain disability, underlying other psychiatric disorders, and longer length of hospital stay were associated with a higher incidence of newly developed depression. In the multivariable Cox regression model, newly acquired depression was associated with a 1.58-fold higher 2-year all-cause mortality compared with that in other patients (hazard ratio: 1.58, 95% confidence interval: 1.38–1.80; P Limitation Lack of information regarding severity and pathologic tumor type. Conclusion Within one follow-up year, 17.0% of patients were newly diagnosed with depression after craniotomy for brain tumor removal. Some factors (old age, living in rural areas, newly acquired brain disability, longer length of hospital stay, and underlying other psychiatric illnesses) could be risk factors for newly diagnosed depression. Furthermore, newly developed depression was associated with an increased 2-year all-cause mortality.
- Subjects :
- Adult
medicine.medical_specialty
medicine.medical_treatment
Brain tumor
Cohort Studies
Risk Factors
Internal medicine
medicine
Humans
Depression (differential diagnoses)
Craniotomy
Aged
Brain Neoplasms
Depression
Proportional hazards model
business.industry
Incidence (epidemiology)
Hazard ratio
Brain
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Cohort
business
Cohort study
Subjects
Details
- ISSN :
- 01650327
- Volume :
- 295
- Database :
- OpenAIRE
- Journal :
- Journal of Affective Disorders
- Accession number :
- edsair.doi.dedup.....8e1b1dcf34553a322c1a5615876f9b36