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Voltammetric determination of Δ9-THC in glassy carbon electrode: An important contribution to forensic electroanalysis
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, LOCUS Repositório Institucional da UFV, Universidade Federal de Viçosa (UFV), instacron:UFV
- Publication Year :
- 2011
-
Abstract
- A new voltammetric method for the determination of Δ9-tetrahydrocannabinol (Δ9-THC) is described. The voltammetric experiments were accomplished in N-N dimethylformamide/water (9:1, v/v), using tetrabutylammonium tetrafluoroborate (TBATFB) 0.1 mol/L as supporting electrolyte and a glassy carbon disk electrode as the working electrode. The anodic peak current was observed at 0.0 V (vs. Ag/AgCl) after a 30 s pre-concentration step under an applied potential of −1.2 V (vs. Ag/AgCl). A linear dependence of Δ9-THC detection was obtained in the concentration range 2.4–11.3 ng/mL, with a linear correlation coefficient of 0.999 and a detection limit of 0.34 ng/mL. The voltammetric method was used to measure the content of Δ9-THC in samples (hemp and hashish) confiscated by the police. The elimination of chemical interferences from the samples was promptly achieved through prior purification using the TLC technique, by employing methanol/water (4:1, v/v) as the mobile phase. The results showed excellent correlation with results attained by HPLC.
- Subjects :
- Detection limit
Working electrode
Supporting electrolyte
CRIMINALÍSTICA
Analytical chemistry
Glassy carbon
Forensic electroanalysis
High-performance liquid chromatography
Pathology and Forensic Medicine
chemistry.chemical_compound
chemistry
Electrode
Tetrahydrocannabinol
Voltammetry
Hashish
Methanol
Law
Hemp
Criminalistics
Subjects
Details
- ISSN :
- 18726283
- Volume :
- 221
- Issue :
- 1-3
- Database :
- OpenAIRE
- Journal :
- Forensic science international
- Accession number :
- edsair.doi.dedup.....8e116d3542d47481a04532e61c8a9fbe