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Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine
- Source :
- Neuroscience. 256:61-71
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Parkinson's disease (PD) is characterized by progressive dopamine (DA) depletion in the striatum. Exercise has been shown to be a promising non-pharmacological approach to reduce the risk of neurodegeneration diseases. This study was designed to investigate the potential neuroprotective effect of swimming training (ST) in a mouse model of PD induced by 6-hydroxydopamine (6-OHDA) in mice. The present study demonstrated that a 4-week ST was effective in attenuating the following impairments resulting from 6-OHDA exposure: (i) depressive-like behavior in the tail suspension test; (ii) increase in the number of falls in the rotarod test; (iii) impairment on long-term memory in the object recognition test; (iv) increase of the reactive species and interleukin 1-beta (IL-1β) levels; (v) inhibition of the glutathione peroxidase (GPx) activity; (vi) rise of the glutathione reductase (GR) and glutathione S-transferase (GST) activities and vii) decrease of DA, homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels. The mechanisms involved in this study are the modulation of GPx, GR and GST activities as well as IL-1β level in a PD model induced by 6-OHDA, protecting against the decrease of DA, DOPAC and HVA levels in the striatum of mice. These findings reinforce that one of the effects induced by exercise on neurodegenerative disease, such as PD, is due to antioxidant and anti-inflammatory properties. We suggest that exercise attenuates cognitive and motor declines, depression, oxidative stress, and neuroinflammation induced by 6-OHDA supporting the hypothesis that exercise can be used as a non-pharmacological tool to reduce the symptoms of PD.
- Subjects :
- Male
medicine.medical_specialty
3,4-Dihydroxyphenylacetic acid
Glutathione reductase
Citrate (si)-Synthase
medicine.disease_cause
Neuroprotection
Hydroxydopamines
Mice
chemistry.chemical_compound
Internal medicine
medicine
Animals
Muscle, Skeletal
Swimming
chemistry.chemical_classification
Glutathione Peroxidase
Hydroxydopamine
Depression
business.industry
General Neuroscience
Glutathione peroxidase
Homovanillic acid
Neurodegeneration
Parkinson Disease
Recognition, Psychology
Catalase
medicine.disease
Corpus Striatum
Exercise Therapy
Mice, Inbred C57BL
Disease Models, Animal
Endocrinology
Hindlimb Suspension
nervous system
chemistry
Rotarod Performance Test
Exploratory Behavior
business
Psychomotor Performance
Oxidative stress
Subjects
Details
- ISSN :
- 03064522
- Volume :
- 256
- Database :
- OpenAIRE
- Journal :
- Neuroscience
- Accession number :
- edsair.doi.dedup.....8e0f0fb9efc1f9fa739815423e812c35