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Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses
Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses
- Source :
- IMMUNITY, Immunity, Immunity, 42(5), 916-928
- Publication Year :
- 2015
-
Abstract
- SummaryThe two major lineages of classical dendritic cells (cDCs) express and require either IRF8 or IRF4 transcription factors for their development and function. IRF8-dependent cDCs promote anti-viral and T-helper 1 (Th1) cell responses, whereas IRF4-expressing cDCs have been implicated in controlling both Th2 and Th17 cell responses. Here, we have provided evidence that Kruppel-like factor 4 (Klf4) is required in IRF4-expressing cDCs to promote Th2, but not Th17, cell responses in vivo. Conditional Klf4 deletion within cDCs impaired Th2 cell responses during Schistosoma mansoni infection, Schistosoma egg antigen (SEA) immunization, and house dust mite (HDM) challenge without affecting cytotoxic T lymphocyte (CTL), Th1 cell, or Th17 cell responses to herpes simplex virus, Toxoplasma gondii, and Citrobacter rodentium infections. Further, Klf4 deletion reduced IRF4 expression in pre-cDCs and resulted in selective loss of IRF4-expressing cDCs subsets in several tissues. These results indicate that Klf4 guides a transcriptional program promoting IRF4-expressing cDCs heterogeneity.
- Subjects :
- Cell
Immunology
Kruppel-Like Transcription Factors
Kruppel-Like Factor 4
Mice
03 medical and health sciences
Th2 Cells
0302 clinical medicine
Antigen
stomatognathic system
medicine
Animals
Cytotoxic T cell
Immunology and Allergy
Cells, Cultured
030304 developmental biology
0303 health sciences
biology
Pyroglyphidae
fungi
Enterobacteriaceae Infections
Herpes Simplex
Dendritic Cells
biology.organism_classification
Asthma
Schistosomiasis mansoni
3. Good health
Mice, Inbred C57BL
Disease Models, Animal
CTL
medicine.anatomical_structure
Infectious Diseases
Gene Expression Regulation
KLF4
Antigens, Helminth
Interferon Regulatory Factors
Schistosoma mansoni
IRF8
Gene Deletion
Toxoplasmosis
030215 immunology
IRF4
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- IMMUNITY, Immunity, Immunity, 42(5), 916-928
- Accession number :
- edsair.doi.dedup.....8dec73b1fe08f1f371110571ec094f80