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Increased serum levels of miR‑214 in patients with PCa with bone metastasis may serve as a potential biomarker by targeting PTEN

Authors :
Zeng‑Hua Zhou
Jun Qiu
Rui‑Lin He
Yi Fang
Sheng‑Rong Xu
Zong‑Bin Jiang
Source :
Oncology Letters.
Publication Year :
2018
Publisher :
Spandidos Publications, 2018.

Abstract

MicroRNAs (miRNAs/miRs) are identified to serve key functions in the progression of various tumors. miR-214 is aberrantly expressed in various types of cancer. In the present study, the function of miR-214 and its feasibility as a potential non-invasive biomarker for patients with prostate cancer (PCa) in a hyperplasia group and a control group were investigated. First, RNA was isolated from the serum of 75 patients with PCa with bone metastasis, 65 patients with PCa with no bone metastasis and 70 healthy controls. The level of miR-214 expression was significantly upregulated in the serum of the bone metastasis group compared with the healthy control and non-bone metastasis groups. Expression levels of alkaline phosphatase (ALP), bone sialoprotein (BSP), collagen type I pyridine crosslinking peptide (ICTP) were also evaluated. The results indicated that serum levels of BSP, ALP and ICTP were increased in the bone metastasis group compared with that in the non-bone metastasis group, hyperplasia group and the control group (P7 (P

Details

ISSN :
17921082 and 17921074
Database :
OpenAIRE
Journal :
Oncology Letters
Accession number :
edsair.doi.dedup.....8de46906f73bf891e1e8447d7ab439e9