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Serotonin, Aggression, and Parental Psychopathology in Children With Attention-Deficit Hyperactivity Disorder
- Source :
- Journal of the American Academy of Child & Adolescent Psychiatry. 36:1391-1398
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- Objective To explore the relationship between central serotonergic (5-HT) function and history of parental aggression in aggressive and nonaggressive boys with attention-deficit hyperactivity disorder (ADHD). Method History of psychiatric symptoms was assessed in the biological parents of 41 boys with ADHD. The relationship between 5-HT function in aggressive and nonaggressive probands, as assessed via the prolactin response to fenfluramine (FEN) challenge, and parental history of aggression was examined. Results Aggressive boys with a parental history of aggressive behavior had a significantly lower prolactin response to FEN challenge than aggressive boys without a parental history of aggression. Nonaggressive boys had a prolactin response midway between those of the two aggressive subgroups, and their prolactin response did not vary as a function of parental aggression. Children subdivided on the basis of parental history of other psychiatric symptoms did not differ in their response to the FEN challenge. Conclusions These data indicate an association between parent aggressive behavior and lower 5-HT function in aggressive boys with ADHD but do not indicate the extent to which this association is environmentally and/or genetically transmitted. There may be different neurochemical mechanisms in familial and nonfamilial aggressive children, which have clinical implications for pharmacological interventions.
- Subjects :
- Adult
Male
Parents
Proband
Serotonin
medicine.medical_specialty
Fenfluramine
Poison control
Neurochemical
Injury prevention
Developmental and Educational Psychology
medicine
Humans
Attention deficit hyperactivity disorder
Child
Psychiatry
Aggression
medicine.disease
Prolactin
Psychiatry and Mental health
El Niño
Attention Deficit Disorder with Hyperactivity
Female
medicine.symptom
Psychology
medicine.drug
Subjects
Details
- ISSN :
- 08908567
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of the American Academy of Child & Adolescent Psychiatry
- Accession number :
- edsair.doi.dedup.....8ddfcf3279b3d643955ed1af7e9ed74f