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Effect of HIV-Infection and Cumulative Viral Load on Age-Related Decline in Grip Strength
- Publication Year :
- 2016
-
Abstract
- OBJECTIVE Grip strength predicts functional decline and death, and is regarded as a biomarker of biological aging. The primary objective of this manuscript was to assess differences in the rate of decline in grip strength in persons aging with and without HIV. DESIGN Grip strength was assessed in 1552 (716 HIV+ and 836 HIV-) men aged at least 50 years participating in the Multicenter AIDS Cohort Study between 2007 and 2014. METHODS Grip strength decline was modeled longitudinally, adjusting for serostatus, demographics, comorbidities, and conditions. In HIV-specific models, coefficients were included for cumulative viral load and history of AIDS. RESULTS Grip strength at the age of 50 years averaged 37.9 and 38.2 kg for HIV+ and HIV- men, respectively (P = 0.70). In fully adjusted models, grip strength declined 0.33 kg/year in HIV- men (P
- Subjects :
- 0301 basic medicine
Male
Aging
Immunology
Multicenter AIDS Cohort Study
HIV Infections
Article
03 medical and health sciences
Grip strength
0302 clinical medicine
Acquired immunodeficiency syndrome (AIDS)
Hand strength
Surveys and Questionnaires
Immunology and Allergy
Medicine
Humans
030212 general & internal medicine
Longitudinal Studies
Muscle Strength
Aged
Hand Strength
business.industry
Hazard ratio
Middle Aged
Viral Load
medicine.disease
030112 virology
Confidence interval
Infectious Diseases
business
Serostatus
Viral load
Demography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8dcdebd298588bfc6e59c1ac6e6bf4d6