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Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil
- Source :
- Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.6 2014, Arquivos Brasileiros de Endocrinologia & Metabologia, Sociedade Brasileira de Endocrinologia e Metabologia (SBEM), instacron:SBEM
- Publication Year :
- 2014
- Publisher :
- FapUNIFESP (SciELO), 2014.
-
Abstract
- Objective: The objective of this study was to determine the prevalence of celiac disease (CD) in adults with autoimmune thyroid disease (ATD) from the endocrinology outpatient setting in a university hospital in Southern Brazil. Subjects and methods: From the years 2007 to 2011, 254 patients with ATD were enrolled consecutively, Grave’s disease was diagnosed in 143 (56.3%) and Hashimoto’s thyroiditis in 111 (43.7%) of them. All patients answered a questionnaire related to symptoms that could be associated with CD and serum samples to screen for IgA anti-endomysial (EmA-IgA) were collected. EmA-IgA-positive patients were offered upper gastrointestinal endoscopy and biopsy of duodenum. Results: A total of 254 patients were included; 222 (87.4%) female, mean age 45.4 ± 13.43 years (18 to 79 years). EmA-IgA was positive in seven patients (2.7%) and five done endoscopy with biopsy. Of these, three diagnosis of CD was confirmed (1.2%). All the three patients with CD had higher EmA-IgA titration, were female and had Hashimoto’s thyroiditis. Like other patients with ATD, CD patients had nonspecific gastrointestinal symptoms, such as heartburn and gastric distention. In our study, one in each 85 patients confirmed the diagnosis of CD. Conclusion: We found a prevalence of 1.2% (1:85) of confirmed CD among Brazilian patients with ATD. Although some IgA-EmA positive patients had Graves’ disease and one was male, all three patients with confirmed CD were female and had Hashimoto’s thyroiditis. Arq Bras Endocrinol Metab. 2014;58(6):625-9
- Subjects :
- Adult
Male
medicine.medical_specialty
Outpatient Clinics, Hospital
endocrine system diseases
Hashimoto's disease
Duodenum
Cross-sectional study
Endocrinology, Diabetes and Metabolism
Graves' disease
Fluorescent Antibody Technique
Hashimoto Disease
Gastroenterology
Thyroiditis
Young Adult
Heartburn
Internal medicine
Biopsy
Prevalence
medicine
Humans
Celiac disease
Outpatient clinic
Young adult
Aged
medicine.diagnostic_test
business.industry
Thyroiditis, Autoimmune
General Medicine
Middle Aged
medicine.disease
Graves Disease
Immunoglobulin A
Surgery
Celiac Disease
Cross-Sectional Studies
Female
medicine.symptom
business
Brazil
Subjects
Details
- ISSN :
- 00042730
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Arquivos Brasileiros de Endocrinologia & Metabologia
- Accession number :
- edsair.doi.dedup.....8dcaa1d388c4405691ce7617bd221b36
- Full Text :
- https://doi.org/10.1590/0004-2730000003003