Back to Search Start Over

Screening of celiac disease in patients with autoimmune thyroid disease from Southern Brazil

Authors :
Renato Nisihara
Gisah Amaral de Carvalho
Ricardo Schmitt de Bem
Cristina Marcatto
Shirley Ramos da Rosa Utiyama
Laila M. Teixeira
Michelli Bertolazo
Source :
Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.6 2014, Arquivos Brasileiros de Endocrinologia & Metabologia, Sociedade Brasileira de Endocrinologia e Metabologia (SBEM), instacron:SBEM
Publication Year :
2014
Publisher :
FapUNIFESP (SciELO), 2014.

Abstract

Objective: The objective of this study was to determine the prevalence of celiac disease (CD) in adults with autoimmune thyroid disease (ATD) from the endocrinology outpatient setting in a university hospital in Southern Brazil. Subjects and methods: From the years 2007 to 2011, 254 patients with ATD were enrolled consecutively, Grave’s disease was diagnosed in 143 (56.3%) and Hashimoto’s thyroiditis in 111 (43.7%) of them. All patients answered a questionnaire related to symptoms that could be associated with CD and serum samples to screen for IgA anti-endomysial (EmA-IgA) were collected. EmA-IgA-positive patients were offered upper gastrointestinal endoscopy and biopsy of duodenum. Results: A total of 254 patients were included; 222 (87.4%) female, mean age 45.4 ± 13.43 years (18 to 79 years). EmA-IgA was positive in seven patients (2.7%) and five done endoscopy with biopsy. Of these, three diagnosis of CD was confirmed (1.2%). All the three patients with CD had higher EmA-IgA titration, were female and had Hashimoto’s thyroiditis. Like other patients with ATD, CD patients had nonspecific gastrointestinal symptoms, such as heartburn and gastric distention. In our study, one in each 85 patients confirmed the diagnosis of CD. Conclusion: We found a prevalence of 1.2% (1:85) of confirmed CD among Brazilian patients with ATD. Although some IgA-EmA positive patients had Graves’ disease and one was male, all three patients with confirmed CD were female and had Hashimoto’s thyroiditis. Arq Bras Endocrinol Metab. 2014;58(6):625-9

Details

ISSN :
00042730
Volume :
58
Database :
OpenAIRE
Journal :
Arquivos Brasileiros de Endocrinologia & Metabologia
Accession number :
edsair.doi.dedup.....8dcaa1d388c4405691ce7617bd221b36
Full Text :
https://doi.org/10.1590/0004-2730000003003