Back to Search Start Over

Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview

Authors :
Andrea Fiorillo
Denise Erbuto
Alberto Forte
Mario Amore
Maurizio Pompili
Gianluca Serafini
Ross J. Baldessarini
Paolo Girardi
Pompili, Maurizio
Baldessarini, Ross J.
Forte, Alberto
Erbuto, Denise
Serafini, Gianluca
Fiorillo, Andrea
Amore, Mario
Girardi, Paolo
Source :
International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 17, Iss 10, p 1700 (2016)
Publication Year :
2016

Abstract

Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general. These preliminary findings encourage further testing of antipsychotics for effects on suicidal behavior, making use of explicit, pre-planned assessments of suicidal behavior.

Details

ISSN :
14220067
Volume :
17
Issue :
10
Database :
OpenAIRE
Journal :
International journal of molecular sciences
Accession number :
edsair.doi.dedup.....8dca477b48edf9898333c4249eb6cdad