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Do Atypical Antipsychotics Have Antisuicidal Effects? A Hypothesis-Generating Overview
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 17, Iss 10, p 1700 (2016)
- Publication Year :
- 2016
-
Abstract
- Modern antipsychotic drugs are employed increasingly in the treatment of mood disorders as well as psychoses, stimulating interest in their possible contributions to altering suicidal risk. Clozapine remains the only treatment with an FDA-recognized indication for reducing suicidal risk (in schizophrenia). We carried out a systematic, computerized search for reports of studies involving antipsychotic drug treatment and suicidal behaviors. A total of 19 reports provide data with preliminary support for potential suicide risk-reducing effects of olanzapine, quetiapine, ziprasidone, aripiprazole, and asenapine in addition to clozapine, and provide some support for antipsychotic drug treatment in general. These preliminary findings encourage further testing of antipsychotics for effects on suicidal behavior, making use of explicit, pre-planned assessments of suicidal behavior.
- Subjects :
- Olanzapine
Suicide Prevention
medicine.medical_treatment
Review
Catalysi
lcsh:Chemistry
0302 clinical medicine
Risk Factors
Asenapine
lcsh:QH301-705.5
Spectroscopy
Clozapine
clozapine
Computer Science Applications1707 Computer Vision and Pattern Recognition
General Medicine
Computer Science Applications
Aripiprazole
medicine.drug
Antipsychotic Agents
medicine.medical_specialty
second-generation
olanzapine
ziprasidone
Catalysis
Inorganic Chemistry
03 medical and health sciences
aripiprazole
medicine
Humans
Ziprasidone
Physical and Theoretical Chemistry
Antipsychotic
Psychiatry
Molecular Biology
suicide
Risperidone
risperidone
business.industry
Organic Chemistry
quetiapine
030227 psychiatry
antipsychotic
asenapine
atypical
lcsh:Biology (General)
lcsh:QD1-999
Atypical
Quetiapine
Second-generation
Suicide
Schizophrenia
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 17
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....8dca477b48edf9898333c4249eb6cdad