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Neurotransplantation in Neurodegenerative Disease: A Survey of Relevant Issues in Developmental Neurobiology
- Source :
- Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231, King's College London
- Publication Year :
- 2008
- Publisher :
- John Wiley & Sons, Ltd, 2008.
-
Abstract
- Neural development and transplantation therapies in neurodegenerative disease share a particular feature. In both cases, undifferentiated neural precursor cells are required to differentiate into a range of neural cell types in a tissue-specific fashion. This similarity opens the possibility that the mechanisms that drive neural development play a similar role in CNS repair. In this chapter, two aspects of neural development are considered in terms of their relevance to CNS repair: the diversity of neural precursor cells and positional specification. We present evidence to suggest that neural stem cells have a degree of diversity that is beyond what might have been expected a priori. We also show that neural stem cells express genes that might encode a positional specification for these cells, and consider a number of hypotheses about the role of positional specification in CNS repair.
Details
- Database :
- OpenAIRE
- Journal :
- Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions: Novartis Foundation Symposium 231, King's College London
- Accession number :
- edsair.doi.dedup.....8dbe3631fa389d1fcd84b7572428dcf1