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Effects of angiotensin I-converting enzyme inhibitor and angiotensin II type 1 receptor blocker on the right ventricular sarcoglycans and dystrophin after left coronary artery ligation
- Source :
- European journal of pharmacology. 522(1-3)
- Publication Year :
- 2005
-
Abstract
- We examined the effects of trandolapril and candesartan on changes in the levels of sarcoglycans and dystrophin in the right ventricle of rats with the left coronary artery ligation. Hemodynamic and morphological alterations suggested the development of hypertrophy of the right ventricle and chronic heart failure by the 8th week. By the end of the 8th week, alpha- and beta-sarcoglycans and dystrophin were decreased. Increases in mu- and m-calpains in the hypertrophied right ventricle were associated with an elevation of casein-proteolytic activity in the cytosolic fraction. Oral administration of 3 mg/kg/day trandolapril or 1 mg/kg/day candesartan from the 2nd to 8th week after the left coronary artery ligation attenuated decreases in alpha-sarcoglycan and dystrophin and reduced the increased proteolytic activity. The results suggest that attenuation of decreases in sarcoglycans and dystrophin is a possible mechanism underlying trandolapril- and candesartan-mediated improvement of structural and functional alterations of the right ventricle in the coronary artery-ligated rat.
- Subjects :
- Male
Indoles
Time Factors
Transcription, Genetic
Myocardial Infarction
Gene Expression
Tetrazoles
Angiotensin-Converting Enzyme Inhibitors
Blood Pressure
Dystrophin
Cytosol
Heart Rate
Medicine
Protein Isoforms
Myocardial infarction
Sarcoglycans
Calpain
Reverse Transcriptase Polymerase Chain Reaction
musculoskeletal system
Coronary Vessels
medicine.anatomical_structure
Circulatory system
Cardiology
medicine.drug
musculoskeletal diseases
Trandolapril
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Heart Ventricles
Blotting, Western
Left coronary artery
Internal medicine
medicine.artery
Animals
RNA, Messenger
Rats, Wistar
Ligation
Pharmacology
business.industry
Biphenyl Compounds
Body Weight
Calcium-Binding Proteins
medicine.disease
Angiotensin II
Rats
Candesartan
Endocrinology
Ventricle
Benzimidazoles
business
Angiotensin II Type 1 Receptor Blockers
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 522
- Issue :
- 1-3
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....8db92d102440b2abe28945018ceb09b3