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Diverse myeloid cells are recruited to the developing and inflamed mammary gland
- Source :
- Immunology. 165:206-218
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The immune system plays fundamental roles in the mammary gland, shaping developmental processes and controlling inflammation during infection and cancer. Here we reveal unanticipated heterogeneity in the myeloid cell compartment during development of virgin, pregnant and involuting mouse mammary glands, and in milk. We investigate the functional consequences of individual and compound chemokine receptor deficiency on cell recruitment. Diverse myeloid cell recruitment was also shown in models of sterile inflammation and bacterial infection. Strikingly, we have shown that inflammation and infection can alter the abundance of terminal end buds, a key developmental structure, within the pubertal mammary gland. This previously unknown effect of inflammatory burden during puberty could have important implications for understanding the control of pubertal timing.
- Subjects :
- Chemokine
Myeloid
Biopsy
Immunology
Cell
Mammary gland
Inflammation
Mastitis
Monocytes
Mice
Chemokine receptor
Mammary Glands, Animal
Immune system
medicine
Animals
Compartment (development)
Immunology and Allergy
Myeloid Cells
biology
Macrophages
Cancer
Flow Cytometry
medicine.disease
Immunohistochemistry
Disease Models, Animal
medicine.anatomical_structure
Cellular Microenvironment
biology.protein
Cytokines
Female
Disease Susceptibility
medicine.symptom
Biomarkers
Granulocytes
Subjects
Details
- ISSN :
- 13652567 and 00192805
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- Immunology
- Accession number :
- edsair.doi.dedup.....8da7b6d4bf369ff42aa391dd321b4bcd