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Neuroprotective Effects of Antidotes in Soman-Poisoned Rats
- Source :
- Acta Medica, Vol 42, Iss 4, Pp 127-131 (1999)
- Publication Year :
- 1999
- Publisher :
- Charles University in Prague, Karolinum Press, 1999.
-
Abstract
- 1. The neuroprotective effects of antidotes (atropine, obidoxime/atropine mixture, HI-6/atropine mixture) on rats poisoned with soman at a sublethal dose (48 μg/kg i.m.; 60% of LD50value) were studied. The neurotoxicity was monitored using a functional observational battery (FOB) and an automatic measurement of motor activity. The neurotoxicity of soman was monitored at 24h and 7d following soman poisoning. 2. The results indicate that atropine alone and the oxime HI-6 in combination with atropine seem to be effective antidotal treatment for the elimination of soman-induced neurotoxicity in the case of sublethal poisonings. 3. On the other hand, the combination of obidoxime with atropine appears to be practically ineffective in diminishing neurotoxic soman-induced symptoms. 4. Dealing with neuroprotective effects of antidotes, the oxime HI-6 in combination with atropine seems to be more suitable antidotal mixture than obidoxime in combination with atropine even in the case of sublethal poisoning with nerve agents.
- Subjects :
- Male
Atropine
Obidoxime
Obidoxime Chloride
050402 sociology
Antidotes
Soman
lcsh:Medicine
Pharmacology
Nervous System
Neuroprotection
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
0504 sociology
Neurotoxicity
Animals
Medicine
Chemical Warfare Agents
Motor activity
Rats, Wistar
Nerve agent
030203 arthritis & rheumatology
business.industry
Poisoning
lcsh:R
05 social sciences
Behavioral screening
General Medicine
medicine.disease
Rats
chemistry
Rat
Cholinesterase Inhibitors
business
medicine.drug
Subjects
Details
- ISSN :
- 18059694 and 12114286
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Acta Medica (Hradec Kralove, Czech Republic)
- Accession number :
- edsair.doi.dedup.....8da3be8faf67bcbd7b1b2b615bf1c2cb