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A study of allergen-specific IgE antibodies in Indian patients of atopic dermatitis
- Source :
- Indian Journal of Dermatology, Venereology and Leprology. 74:100
- Publication Year :
- 2008
- Publisher :
- Scientific Scholar, 2008.
-
Abstract
- Background: Atopic dermatitis (AD) is a chronic, relapsing, pruritic dermatitis frequently associated with the hyperproduction of IgE to various allergens. Identification of these allergens is possible by various laboratory investigations. Aim: The present study was designed to assess these allergen-specific antibodies in the diagnosis of AD in the Indian context. Methods: This prospective study comprised 50 patients of AD. The diagnosis was made clinically after satisfying Hanifin and Rajka's criteria. Serum IgE levels were estimated and specific IgE antibodies were measured for 20 food allergens and aeroallergens. Results: Serum IgE was elevated in 88% of the patients. The highest elevation of mean IgE levels was seen in the 10-20 years age group. Sixty five percent of the children under the age of ten years were positive to one or more food allergens. Food allergens were more often positive in the ≤10 years age group and specific antibodies to inhalants were seen more frequently in the older age groups. Specific antibodies to apples were found in all age groups. Conclusion: Antibodies against apples and hazelnuts were the more commonly seen specific antibodies in children. Incidence of positivity was much higher in children when compared to earlier studies. Identification of food allergens can be an important factor in the diagnosis of AD in children in India. Positivity to inhalant allergens in the older age groups was lower in this study. The allergen profile with regard to inhalants in Indian patients was similar to that of earlier studies.
- Subjects :
- Adult
Male
medicine.medical_specialty
Allergy
Adolescent
India
Context (language use)
Dermatology
medicine.disease_cause
Immunoglobulin E
Dermatitis, Atopic
Atopy
Allergen
medicine
Humans
Prospective Studies
Child
biology
medicine.diagnostic_test
business.industry
Radioallergosorbent test
Incidence (epidemiology)
Infant
Atopic dermatitis
Allergens
medicine.disease
Infectious Diseases
Child, Preschool
Immunology
biology.protein
Female
business
Food Hypersensitivity
Subjects
Details
- ISSN :
- 03786323
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Dermatology, Venereology and Leprology
- Accession number :
- edsair.doi.dedup.....8da06a0ee825e1d1959e5ed6c1e2e69d