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Carinal reconstruction with a Y-shaped collagen-conjugated prosthesis
- Source :
- The Journal of Thoracic and Cardiovascular Surgery. (6):1162-1168
- Publisher :
- American Association for Thoracic Surgery. Published by Mosby, Inc.
-
Abstract
- Background: Carinal reconstruction by direct suturing is associated with a high mortality because high tension at the anastomosis can lead to tracheobronchial fistula. A new tracheal prosthesis was therefore designed for reconstruction of the tracheal bifurcation and applied for experimental carinal replacement in dogs. Methods: The main frame of the new prosthesis consists of a Y-shaped Marlex mesh tube (C.R. Bard, Inc, Billerica, Mass) reinforced with polypropylene spirals, to which collagen extracted from porcine skin is chemically conjugated to provide biocompatibility and airtightness. This conjugated collagen is composed of amorphous and sponge collagen layers. The tracheobronchial bifurcation was replaced with the prosthesis in 10 beagle dogs. Results: Eight dogs survived the postoperative period, and 2 dogs died within 4 days after the operation. Bronchoscopic examination revealed that the tracheal prosthesis was covered with smooth whitish tissue and that no stenosis or dehiscence was present in the 8 dogs even 6 months after the operation. Slight mesh exposure was recognized in 1 dog. Histologic examination revealed that approximately one half of the luminal surface was covered with ciliated columnar epithelium or nonciliated squamous epithelium. In the remaining lumen, especially in the middle portion of the prosthesis, connective tissue without epithelium was observed. Conclusions: These long-term results indicate that our bifurcated tracheal prosthesis can be used for reconstruction of the tracheobronchial bifurcation with long-term safety. (J Thorac Cardiovasc Surg 2000;119:1162-8)
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Time Factors
Fistula
medicine.medical_treatment
Lumen (anatomy)
Connective tissue
Bronchi
Dehiscence
Anastomosis
Polypropylenes
Prosthesis
Dogs
medicine
Animals
Bioprosthesis
business.industry
Ciliated columnar epithelium
Anatomy
medicine.disease
Surgery
Trachea
Stenosis
medicine.anatomical_structure
Artificial Organs
Collagen
business
Cardiology and Cardiovascular Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 00225223
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Journal of Thoracic and Cardiovascular Surgery
- Accession number :
- edsair.doi.dedup.....8d916cca26c3b6197d8ac81302d5e473
- Full Text :
- https://doi.org/10.1067/mtc.2000.106652