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High-throughput ultraviolet photoacoustic microscopy with multifocal excitation
- Source :
- Journal of Biomedical Optics. 23:1
- Publication Year :
- 2018
- Publisher :
- SPIE-Intl Soc Optical Eng, 2018.
-
Abstract
- Ultraviolet photoacoustic microscopy (UV-PAM) is a promising intraoperative tool for surgical margin assessment (SMA), one that can provide label-free histology-like images with high resolution. In this study, using a microlens array and a one-dimensional (1-D) array ultrasonic transducer, we developed a high-throughput multifocal UV-PAM (MF-UV-PAM). Our new system achieved a [Formula: see text] lateral resolution and produced images 40 times faster than the previously developed point-by-point scanning UV-PAM. MF-UV-PAM provided a readily comprehensible photoacoustic image of a mouse brain slice with specific absorption contrast in [Formula: see text] , highlighting cell nuclei. Individual cell nuclei could be clearly resolved, showing its practical potential for intraoperative SMA.
- Subjects :
- Materials science
Research Papers: Imaging
Transducers
Microscopy, Acoustic
Biomedical Engineering
medicine.disease_cause
01 natural sciences
Photoacoustic Techniques
010309 optics
Biomaterials
Mice
03 medical and health sciences
0302 clinical medicine
0103 physical sciences
Image Processing, Computer-Assisted
medicine
Animals
Image resolution
Throughput (business)
Ultrasonography
Microlens
Brain
Equipment Design
SMA
Atomic and Molecular Physics, and Optics
High-Throughput Screening Assays
Electronic, Optical and Magnetic Materials
Transducer
Surgery, Computer-Assisted
030220 oncology & carcinogenesis
Ultrasonic sensor
Algorithms
Ultraviolet
Excitation
Biomedical engineering
Subjects
Details
- ISSN :
- 10833668
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....8d88bca83f99afa11f1fb26e4e3c7028