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Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana
- Source :
- Virology Journal, Vol 9, Iss 1, p 78 (2012), Virology Journal
- Publication Year :
- 2012
- Publisher :
- BMC, 2012.
-
Abstract
- Background Acute respiratory tract infections are one of the major causes of morbidity and mortality among young children in developing countries. Information on the viral aetiology of acute respiratory infections in developing countries is very limited. The study was done to identify viruses associated with acute lower respiratory tract infection among children less than 5 years. Method Nasopharyngeal samples and blood cultures were collected from children less than 5 years who have been hospitalized for acute lower respiratory tract infection. Viruses and bacteria were identified using Reverse Transcriptase Real-Time Polymerase Chain Reaction and conventional biochemical techniques. Results Out of 128 patients recruited, 33(25.88%%, 95%CI: 18.5% to 34.2%) were positive for one or more viruses. Respiratory Syncytial Virus (RSV) was detected in 18(14.1%, 95%CI: 8.5% to 21.3%) patients followed by Adenoviruses (AdV) in 13(10.2%, 95%CI: 5.5% to 16.7%), Parainfluenza (PIV type: 1, 2, 3) in 4(3.1%, 95%CI: 0.9% to 7.8%) and influenza B viruses in 1(0.8%, 95%CI: 0.0 to 4.3). Concomitant viral and bacterial co-infection occurred in two patients. There were no detectable significant differences in the clinical signs, symptoms and severity for the various pathogens isolated. A total of 61.1% (22/36) of positive viruses were detected during the rainy season and Respiratory Syncytial Virus was the most predominant. Conclusion The study has demonstrated an important burden of respiratory viruses as major causes of childhood acute respiratory infection in a tertiary health institution in Ghana. The data addresses a need for more studies on viral associated respiratory tract infection.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
viruses
Population
Respiratory Viruses
Ghana
Virus
lcsh:Infectious and parasitic diseases
Nasopharynx
Virology
Internal medicine
Prevalence
medicine
Humans
lcsh:RC109-216
Respiratory system
education
Respiratory Tract Infections
education.field_of_study
Respiratory tract infections
Clinical Laboratory Techniques
business.industry
Research
Infant
Respiratory infection
Reverse transcriptase
Hospitalization
Blood
Cross-Sectional Studies
Infectious Diseases
medicine.anatomical_structure
Virus Diseases
Child, Preschool
Viruses
Etiology
Female
Hospitalized children
Real-Time PCR
business
Respiratory tract
Subjects
Details
- Language :
- English
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Virology Journal
- Accession number :
- edsair.doi.dedup.....8d85c3879523c6c3a39a9af460c840d8