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Influence of 1-Week Helicobacter pylori Eradication Therapy with Rabeprazole, Clarithromycin, and Metronidazole on 13C-Aminopyrine Breath Test
- Source :
- Digestive Diseases and Sciences. 50:1207-1213
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- Helicobacter pylori eradication therapy is commonly prescribed in the general population. Treatment consists of drugs that are mainly metabolized by the liver cytochrome P-450 (CYP) enzymatic pool. Most H. pylori-infected patients often take drugs for comorbid illnesses, therefore increasing the potential for drug-drug interactions. We aimed to evaluate the interactions of rabeprazole, clarithromycin, and metronidazole 1-week H. pylori eradication therapy with CYP-dependent liver metabolic function in clinical practice. Ten patients referred to our unit for H. pylori infection underwent 1-week eradication therapy with rabeprazole (20 mg, b.i.d.), clarithromycin (500 mg, b.i.d.), and metronidazole (500 mg, b.i.d.). We chose the 13C-aminopyrine breath test (13C-ABT) to evaluate CYP-dependent liver function since it is noninvasive and nonharmful. All patients underwent 13C-ABT at three time points: before therapy (to), at the end of therapy (t8), and after 1 month of follow-up (t38). Mean 13C-ABT dose/hr (t0 = 14.0 +/- 5.4, t8 = 13.5 +/- 4.0, t38 = 16.1 +/- 5.6) as well as 13C-ABT cumulative dose (t0 = 2.4 +/- 1.1, t8 = 2.4 +/- 0.8, t38 = 2.6 +/- 1.0) were not statistically different at the three time points of the study. These results did not seem to be influenced by drugs being administered concomitantly. In everyday clinical practice rabeprazole-based H. pylori eradication therapy does not seem to display any significant interactions with CYP-dependent liver function, even in patients on multiple drugs.
- Subjects :
- Male
medicine.medical_specialty
Physiology
Population
Rabeprazole
Pharmacology
Gastroenterology
2-Pyridinylmethylsulfinylbenzimidazoles
Helicobacter Infections
Anti-Infective Agents
Cytochrome P-450 Enzyme System
Liver Function Tests
Clarithromycin
Metronidazole
Internal medicine
medicine
Humans
Drug Interactions
Enzyme Inhibitors
Aminopyrine
education
Aged
Antibacterial agent
Breath test
Carbon Isotopes
education.field_of_study
Helicobacter pylori
medicine.diagnostic_test
biology
Chemistry
Middle Aged
biology.organism_classification
Anti-Bacterial Agents
Breath Tests
Liver
Benzimidazoles
Drug Therapy, Combination
Female
Liver function
Omeprazole
medicine.drug
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi.dedup.....8d83ab0e4064f496eae1bac1b720eed6