Back to Search
Start Over
Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer
- Source :
- Cancer and Metastasis Reviews. 35:201-212
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Olfactomedin 4 (OLFM4) is an olfactomedin domain-containing glycoprotein. Multiple signaling pathways and factors, including NF-κB, Wnt, Notch, PU.1, retinoic acids, estrogen receptor, and miR-486, regulate its expression. OLFM4 interacts with several other proteins, such as gene associated with retinoic-interferon-induced mortality 19 (GRIM-19), cadherins, lectins, nucleotide oligomerization domain-1 (NOD1) and nucleotide oligomerization domain-2 (NOD2), and cathepsins C and D, known to regulate important cellular functions. Recent investigations using Olfm4-deficient mouse models have provided important clues about its in vivo biological functions. Olfm4 inhibited Helicobacter pylori-induced NF-κB pathway activity and inflammation and facilitated H. pylori colonization in the mouse stomach. Olfm4-deficient mice exhibited enhanced immunity against Escherichia coli and Staphylococcus aureus infection. Olfm4 deletion in a chronic granulomatous disease mouse model rescued them from S. aureus infection. Olfm4 deletion in mice treated with azoxymethane/dextran sodium sulfate led to robust intestinal inflammation and intestinal crypt hyperplasia. Olfm4 deletion in Apc Min/+ mice promoted intestinal polyp formation as well as adenocarcinoma development in the distal colon. Further, Olfm4-deficient mice spontaneously developed prostatic epithelial lesions as they age. OLFM4 expression is correlated with cancer differentiation, stage, metastasis, and prognosis in a variety of cancers, suggesting its potential clinical value as an early-stage cancer marker or a therapeutic target. Collectively, these data suggest that OLFM4 plays important roles in innate immunity against bacterial infection, gastrointestinal inflammation, and cancer. In this review, we have summarized OLFM4’s initial characterization, expression, regulation, protein interactions, and biological functions.
- Subjects :
- 0301 basic medicine
Cancer Research
Inflammation
Biology
03 medical and health sciences
Immunity
Neoplasms
NOD2
Granulocyte Colony-Stimulating Factor
NOD1
medicine
Animals
Humans
Innate immune system
NF-kappa B
Wnt signaling pathway
Cancer
Bacterial Infections
medicine.disease
Immunity, Innate
MicroRNAs
030104 developmental biology
Gene Expression Regulation
Oncology
Immunology
Cancer research
medicine.symptom
Signal transduction
Carrier Proteins
Protein Binding
Signal Transduction
Subjects
Details
- ISSN :
- 15737233 and 01677659
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Cancer and Metastasis Reviews
- Accession number :
- edsair.doi.dedup.....8d7e752a4ea17f3680278d2c836ba849
- Full Text :
- https://doi.org/10.1007/s10555-016-9624-2