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Association between exercise habits and subcortical gray matter volumes in healthy elderly people: A population-based study in Japan
- Source :
- eNeurologicalSci, Vol 7, Iss C, Pp 1-6 (2017), eNeurologicalSci
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background and aims The relationship between exercise and subcortical gray matter volume is not well understood in the elderly population, although reports indicate that exercise may prevent cortical gray matter atrophy. To elucidate this association in the elderly, we measured subcortical gray matter volume and correlated this with volumes to exercise habits in a community-based cohort study in Japan. Methods Subjects without mild cognitive impairment or dementia (n = 280, 35% male, mean age 73.1 ± 5.9 years) were evaluated using the Mini-Mental State Examination (MMSE), an exercise habit questionnaire, and brain magnetic resonance imaging. Subcortical gray matter volume was compared between groups based on the presence/absence of exercise habits. The MMSE was re-administered 3 years after the baseline examination. Results Ninety-one subjects (32.5%) reported exercise habits (exercise group), and 189 subjects (67.5%) reported no exercise habits (non-exercise group). Volumetric analysis revealed that the volumes in the exercise group were greater in the left hippocampus (p = 0.042) and bilateral nucleus accumbens (left, p = 0.047; right, p = 0.007) compared to those of the non-exercise group. Among the 195 subjects who received a follow-up MMSE examination, the normalized intra-cranial volumes of the left nucleus accumbens (p = 0.004) and right amygdala (p = 0.014)showed significant association with a decline in the follow-up MMSE score. Conclusion Subjects with exercise habits show larger subcortical gray matter volumes than subjects without exercise habits in community-dwelling elderly subjects in Japan. Specifically, the volume of the nucleus accumbens correlates with both exercise habits and cognitive preservation.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Nucleus accumbens
lcsh:RC346-429
03 medical and health sciences
0302 clinical medicine
Atrophy
Medicine
Dementia
Exercise
lcsh:Neurology. Diseases of the nervous system
business.industry
Depression
Cognition
Healthy elderly
medicine.disease
Subcortical gray matter
Population based study
030104 developmental biology
Neurology
Physical therapy
Original Article
Cognitive function
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 24056502
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- eNeurologicalSci
- Accession number :
- edsair.doi.dedup.....8d78eab01f60ea22a061190babc43e93
- Full Text :
- https://doi.org/10.1016/j.ensci.2017.03.002