Back to Search
Start Over
Oxytocin and vasopressin 1a receptor gene expression in the cycling or pregnant human uterus
- Source :
- American Journal of Obstetrics and Gynecology. 179:1572-1578
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Objective: Our purpose was to compare concentrations of messenger ribonucleic acid specific for the oxytocin receptor and for the vasopressin 1a receptor in myometrial and endometrial tissues of pregnant and nonpregnant women. Study Design: Tissues from pregnant uteri were obtained from 95 women who were undergoing cesarean delivery between 26 and 42 weeks' gestation. Tissues from nonpregnant uteri were obtained from 7 cycling women who were undergoing hysterectomy. The competitive reverse-transcription polymerase chain reaction method was used to determine messenger ribonucleic acid concentrations. Results: A significant increase in oxytocin receptor messenger ribonucleic acid was found during the first half of pregnancy. Oxytocin receptor messenger ribonucleic acid concentrations were lower in tissues with spontaneous contractions than in quiescent tissues and were decreased in patients with advanced labor. Vasopressin 1a receptor messenger ribonucleic acid concentrations were high in tissues from both cycling and pregnant uteri but remained unchanged throughout gestation. Conclusion: The increase in oxytocin receptor protein concentrations seen in pregnancy is only partially controlled by messenger ribonucleic acid abundance. High concentrations of vasopressin 1a receptor messenger ribonucleic acid confirm the biologically active role of this receptor in both the cycling and the pregnant uterus. (Am J Obstet Gynecol 1998;179:1572-8.)
- Subjects :
- Receptors, Vasopressin
medicine.medical_specialty
Vasopressin
Pregnancy Trimester, Third
Uterus
Gene Expression
Neuropeptide
Peptide hormone
Oxytocin
Endometrium
Pregnancy
Internal medicine
medicine
Humans
RNA, Messenger
Receptor
Menstrual Cycle
reproductive and urinary physiology
Vasopressin receptor
Labor, Obstetric
Reverse Transcriptase Polymerase Chain Reaction
business.industry
Obstetrics and Gynecology
Oxytocin receptor
Endocrinology
medicine.anatomical_structure
Pregnancy Trimester, Second
Myometrium
Female
business
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 179
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....8d5b326ace46f491f5314381fac8ea3a