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Expression and regulation of Nkd-1, an intracellular component of Wnt signalling pathway in the chick embryo
- Source :
- Anatomy and embryology. 211(5)
- Publication Year :
- 2006
-
Abstract
- The Wnt family of secreted signalling molecules control a wide range of developmental processes in all metazoans. The intracellular response to Wnt signalling depends on the choice of signalling cascade activated in the responding cell. Cells can activate either the canonical pathway that modulates gene expression to control cellular differentiation and proliferation, or the non-canonical pathway that controls cell polarity and movement. Recent work has identified the protein Naked Cuticle to act as an intracellular switch to promote the non-canonical pathway at the expense of the canonical pathway. We have cloned chick Naked Cuticle-1 (cNkd-1) and show that it is expressed in a dynamic manner during early embryogenesis. We show that it is expressed in the somites and in particular regions where cells are undergoing movement. Lastly, we show that the expression of cNkd-1 is regulated by Wnt expression originating from the neural tube. This study provides evidence that non-canonical Wnt signalling plays a part in somite development.
- Subjects :
- Embryology
Embryo, Nonmammalian
Cellular differentiation
Molecular Sequence Data
Notochord
Chick Embryo
Biology
Cell polarity
medicine
Paraxial mesoderm
Animals
Amino Acid Sequence
Phylogeny
Base Sequence
Wnt signaling pathway
LRP6
Gene Expression Regulation, Developmental
LRP5
Cell Biology
Cell biology
Naked cuticle
Wnt Proteins
Somite
medicine.anatomical_structure
Somites
Anatomy
Carrier Proteins
Chickens
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 03402061
- Volume :
- 211
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Anatomy and embryology
- Accession number :
- edsair.doi.dedup.....8d55cd58baf935a684295e747fa968ff